Basic Information

Symbol
NR1I3
RNA class
mRNA
Alias
Nuclear Receptor Subfamily 1 Group I Member 3 CAR Constitutive Androstane Receptor MB67 CAR1 Constitutive Activator Of Retinoid Response Constitutive Active Response Orphan Nuclear Receptor MB67 Nuclear Receptor Subfamily 1, Group I, Member 3 Orphan Nuclear Hormone Receptor Constitutive Active Receptor
Location (GRCh38)
1:161229666-161238262
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005122.5
Sequence length
1371.0 nt
GC content
0.5419

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-474.90 kcal/mol
Thermodynamic ensemble
Free energy: -503.15 kcal/mol
Frequency: 0.0000
Diversity: 340.23
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..........((((((.(((...((.(((.((((..(((((..........((((((...((((........))))...(((((....)).)))....((((((...(((..((.....((((((((((..(((((((........))))...)).)..))).))))))).))..))).))))))..((((....)))))))))))))))..)))).)))))...)))...((((.(((((.((((((((...)))).........(((((((((((.((.....(((.(((.....))))))....)))))))))....))))))))))))).))))((......))...(((((((((..(...(((.((((((((.(((..(((((((.(((....(((....))).....))).))).)).))...((((......))))(((....)))...((.((((.....)))).)).((((.((.((.((((((((.......))))((...(((.....(((((.((.((((((..((((......))))(((((((...........))))).))..((((((((.((....)).))))))))...)))))).))))))).....)))...))....)))).))))))))...))).))))))))))).)..))))))))).........(((((((.....(((((.((((...(((..((..(((((((((((((((..((.(((.((..(((((..((((((((((((((...)))))))...........))))).......))..))))).(((((((.(((.((((.................(((((((((((((.........))))))..).))))))..((((((((((((.((((((((((((((((..((((..................))))...))))))))))))...((((((((.((.(((((((((...(((((((((.(((((((...(((.....)))...))).)))).))))(((((.(((((((.(((.((......))..))))))..))))..))))))))))(((((((.((((((..((((.((((((...((((...(..(((.((((....)))).)))..)...))))....))))))...((((.....)))).....)))).))))))(((......)))..)))))))...........)))))))))))))))))))............))))))))))))).))))))).)))..)))))))......)).)))))..)))).)))).)))))))..))..)))...))))))))))))))))...)))))).
Thermodynamic Ensemble Prediction
.,,,,.....||||{{,(((...{{.{((,({{{..{|||{.....,,,,,((((({..,((((..,,,,,,|||,...{((((..,,|},|}|..{{((((((...(((..{{,....((((((((((..((({{(({{......|})),,.}).)..))))}))))))})}..))).)))))},.{{{{....)))}}||||}}}|}}..}}}},}}|}},..}}|.{.((((.((((((((({((((...))))........,((((((((((({{(,,,,,(((.{{{,,..,)))))},...}})))))))....))))))))))))).)))),|.,{{||||,.{((({{{{({,,|,..{((,(((((((({(,({{{{{{(((,(({,.,,((|...,|||,....|||,|||,}}.|,...{{{{......))))|||,...))},,}||,|{{{.}}.,|)},.))||||{|||.||,|{((({((.......})))))..,{{|,,..,((((,{((.((((((..((((......))))((((({{...........})))).))..((((((((.((....)).))))))))...)))))).))))))).....)}}.,,)}...}}))).}}))))}),}})))}))))))))))).,..||||}||||.,.,,....{{{{{{{....,|||||,|{{{...{{{..{{..(((((((((((((((..({((((.((..,{(({.,{{{{{,,(((((({...}))))))....|{{{{...,,,.})}},..},..,},,,.(((((((.(((.((((................,(((((((((((({.........}))))).}).)))))),.((((((((((((.((((((((((((((((..((((........,,........)))}...)))))))))))}|..((((((((.((.(((((((((..,(((((((,({(((({((...{{{...,.)))...)))})))).))},{((((.((((((,{(((.,(......,)..)))))),.})))..))))))))))|((((((.((((((..((((.((((((...((((...(..(((.((((....)))).)))..)...))))....))))))...((((.....)))).....)))).)))))){((......)))..))))))}...,.....,.)))))))))))))))))))............))))))))))))).))))))).)))..)))))))......)).)))))..)))),,)))},))))))..}),}))},,,)))))))}}}))))))....,}}}}.

Transcripts

ID Sequence Length GC content
NM_001077479.3 NCBI
AGACAUCUCUUGUUUUCCAGAUACUACGGGUCAUAAUCCCUAACUCCAA… 1231 nt 0.5410
NM_001077480.3 NCBI
AGACAUCUCUUGUUUUCCAGAUACUACGGGUCAUAAUCCCUAACUCCAA… 1383 nt 0.5416
NM_001077481.3 NCBI
AGACAUCUCUUGUUUUCCAGAUACUACGGGUCAUAAUCCCUAACUCCAA… 1269 nt 0.5437
NM_001077482.3 NCBI
AGACAUCUCUUGUUUUCCAGAUACUACGGGUCAUAAUCCCUAACUCCAA… 1398 nt 0.5408
NM_005122.5 NCBI
AGACAUCUCUUGUUUUCCAGAUACUACGGGUCAUAAUCCCUAACUCCAA… 1371 nt 0.5419
Showing 11 to 15 of 15 entries
Summary

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

Forensic Context

A study in a Wistar rat model of acute carbon dioxide poisoning demonstrated that the NR1I3 mRNA expression levels in the hypothalamus were not significantly different between any experimental CO2 exposure groups and the control group [Sato et al. DOI:10.1016/J.Legalmed.2015.07.014]. A study in human myocardial samples from explanted hearts demonstrated that the NR1I3 mRNA expression was significantly upregulated in dilated cardiomyopathy (8.16-fold, p < 0.0002) and ischemic cardiomyopathy (4.33-fold, p < 0.002) compared to a healthy control group [Tatrai et al. DOI:10.1016/J.Forsciint.2011.05.010].