Basic Information

Symbol
NRGN
RNA class
mRNA
Alias
Neurogranin RC3 Neurogranin (Protein Kinase C Substrate, RC3) Calmodulin-Binding Protein Protein Kinase C Substrate Hng Ng
Location (GRCh38)
11:124739939-124747210
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006176.3
Sequence length
1210.0 nt
GC content
0.6413

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-471.00 kcal/mol
Thermodynamic ensemble
Free energy: -489.59 kcal/mol
Frequency: 0.0000
Diversity: 311.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((((((((.((((((((((((((..((.(((((..((((((.(((((.((((((....((.((..(((((..((......((((((.(.((((((((((...((....))...)))))(((.(((((((...(((((..(((.(((((.........((((.(((...))).)).)).........))).))))).))))).....(((((.(((....(((((((((((........))))..(((((.(.(((....))).).))))).........((.....)))))))))....))))))))...))))))))))))))).).)))))))).)))))..)).))))))))))))))))))((((((((((((((((((((((((.((((..((((((((((((....(((((...)))))...((((((..(((.(.(......)))))..))))))....((((((...(((.........))).))))))...(((((.(....(((.....)))....).))))))))).))).)))).)..))))...))))........)))))))))..)))))))((((...))))...........)))).................(((....(((...........))).....)))......)..))))).)).)))).))))))))))))).((((((.((((((((........)))))))).))((((((((((.(((.........(((((...((..((((((........)))))).))..)))))...)))....)))))))))).((((((............(((((.((...)).((((....))))....))))))))))).(((((.(((((((((((.......))))))))))).((((.......))))...))))).........)))).(((((((((((..........((((((((((((..((((....))))..))).......(((((((((.((((.(((.(((((((((((((........)))))))))).)))...........(((.(((((((.(((((...(((....))).....))))).).)))))).)))........))).)))).)))))).))))))))))))..)))))))).))).......))...)))).........
Thermodynamic Ensemble Prediction
..,,.(((({{(((.((((((((((((((..((.(((((..{(((((.(((((.((((((....(({,{..(({((,.{{......,{((((.{.((((((((((...((....))...)))))(((.(((((({...{((((..(({.||{||....,.,..((((.(((...})}.)).}}.........}}).),))).)))))..,..(((((.(((....(((((((((((........))))..{((((.(.(((....))).).))))}.........((.....)))))))))....))))))))..|,)))))))))))))).}.)))))))).)})))|.)),|})))))))))))))))){{{{(((((((((((((((((({{.,,,,..{{{{,,((((,(.{{(({{{.,.,||}},,|,|||,.((((((.(,....((((((|(,,{{(|((,...((((((...(((.........))).))))))....,,|.|||.}}}||}}....}},,.,,))))))}))))))))))|},},,,)}}}}}))}}........)))))))))..))))))),{((,..,}.,..},,...,,.,,}}.................|||},,,|,,.....,.....}})|....,))......,..))))).)).)))).))))))))))))).((((((.((((((((........)))))))).))((((((((((.(((,,.......(((((...,,..{{{({{...,,,,.}}}})),)),.))))),,.)))....)))))))))).{{{{{,.,,..,,.,,.{(((((.{(,.,|,.{{,...,.,,))....)))))),)))).{((({.{(((((((((({{....|})))))))))).{|||...,}},)}))...,)))).}}},....}}}}.(((((((((((..........((((((((((((..((((....))))..))).......(((((((((.((((.(((.(((((((((((((........)))))))))).)))...{{...||,(({.{((((({.(({{{...,,{.,..))).....))))).).)))))}.)))........))).)))).)))))).))))))))))))..))))))))},)).......})...))))..,.,,...

Transcripts

ID Sequence Length GC content
NM_001126181.2 NCBI
AGACCGGACCCGAGAGCAGAGCUGCUGUUUCGGCGCGGGUCGGCUGGCG… 1213 nt 0.6406
NM_006176.3 NCBI
AGACCGGACCCGAGAGCAGAGCUGCUGUUUCGGCGCGGGUCGGCUGGCG… 1210 nt 0.6413
Summary

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the NRGN (Nrgn) mRNA expression was significantly increased specifically in the brainstem of subjects exposed to carbon dioxide intoxication compared to controls and those subjected to asphyxia due to oxygen deficiency, identifying it as a potential diagnostic marker for differentiating these causes of death [Yatsushiro et al. DOI:10.1007/S12024-025-00981-1]. In human forensic science, the NRGN was selected as a blood-specific candidate gene from genome-wide mRNA profiling and was successfully validated by RT-PCR for its specific expression in blood samples, contributing to body fluid identification [Park et al. DOI:10.1016/j.fsigen.2012.09.001].