Basic Information

Symbol
NUDT1
RNA class
mRNA
Alias
Nudix Hydrolase 1 7,8-Dihydro-8-Oxoguanine Triphosphatase Nudix Motif 1 8-Oxo-DGTPase MTH1 Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 Nucleoside Diphosphate-Linked Moiety X-Type Motif 1 Methylated Purine Nucleoside Triphosphate Hydrolase Oxidized Purine Nucleoside Triphosphate Hydrolase 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase Nucleoside Diphosphate-Linked Moiety X Motif 1 8-Oxo-7,8-Dihydroguanosine Triphosphatase 2-Hydroxy-DATP Diphosphatase MutT Human Homolog 1 EC 3.6.1.56 EC 3.6.1.-
Location (GRCh38)
7:2242203-2251824
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002452.4
Sequence length
658.0 nt
GC content
0.6033

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-269.00 kcal/mol
Thermodynamic ensemble
Free energy: -280.31 kcal/mol
Frequency: 0.0000
Diversity: 242.83
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........(((((((((..(((.((.(...(..((((((((..((((((.(((((.((((((((.((.....((((((((((.((((((.((...(((..........)))...)))))))).))))))))))((((((.....((((..(.((...)).)..))))......)))))).)))))))))).)))))..))((((((......(((.(((......))))))))))))((..((((((((..((((((((..((((((((((........))))))))))((((.(((((.......)))))))))(((.(((...))).))).)))).))))..)).))))))..))..(((.((((((((...(((((((...(((..(((((((((...........(((((((..((.(((...))).))..))))..))))))))......(((.(((((((..((...)))))))))))).)))).)))..)))).)))...)))))))).)))((((((((....)))))))).......(((((((.....)))))))...))))..)).))))))..)....).)).)))....)))))((((((((((......))))))))))...........(((....)))))))
Thermodynamic Ensemble Prediction
....((({(((((((((..(((,,{,(|,,{..(((((((,..(((({.((({{{{||||||||.||||||.((((((((((.((((((.((...(((..........)))...)))))))).))))))))))}||{||.,|}}||||}}|}|}.,,(({(..{,,((,{,..||{((.,{},|||((({{({((((,{{{(((((,{,...{{{(((({.,,,||||}|||}}||,....{(((((((.,({((,((({,((((((((((........)))))))))){(((.{({{{..,,,,.}}}}}|}|((((,(((,,,}}|,|||,|,||,.},,..})}})))))}},)))))),.))})}),,,.}}.}}})),,).}),}{||||}}..,..{{|||,|}}||||||.}||}||||||,...||,|...,}|}.}.,)},}}}..{{||(((((({..{{...))})))))))))...,.,{||||,,||||{|,...})))}))))},((((((((....)))))))).||}},,(((((((.....)))))))...))})}})).,)))))}})....,}))}),}...,|||}|((((((((((......)))))))))}...........{||.,,,)))}}}.

Transcripts

ID Sequence Length GC content
NM_001367553.1 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUACGAAAAGCGCGCGCG… 742 nt 0.5984
NM_001367554.1 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUACGAAAAGCGCGCGCG… 836 nt 0.5969
NM_001367555.1 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGAACCCAGGGACCAUGGGC… 752 nt 0.6011
NM_002452.4 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGAACCCAGGGACCAUGGGC… 658 nt 0.6033
NM_198948.2 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUUUCUUGCCUUGAUGUA… 709 nt 0.5966
NM_198949.2 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUUUCUUGCCUUGAUGUA… 782 nt 0.5908
NM_198950.2 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUACGAAAAGCGCGCGCG… 745 nt 0.5987
NM_198952.2 NCBI
AGAGGCCACGCCCCCGGAAGCGGCGGUGCAGGUACGAAAAGCGCGCGCG… 818 nt 0.5929
NM_198953.1 NCBI
AGGGCUUUCUGUAUCCCUAGGUUUCUUGCCUUGAUGUACUGGAGCAAUC… 728 nt 0.5618
NM_198954.1 NCBI
AGGGCUUUCUGUAUCCCUAGGUUUCUUGCCUUGAUGUACUGGAGCAAUC… 801 nt 0.5593
Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

Forensic Context

A study in mice demonstrated that the NUDT1 was identified as a core feature gene closely associated with elevated oxidative stress levels in sepsis, primarily expressed in dendritic cells [Tao et al. DOI:10.1007/s10753-025-02346-w].