Basic Information

Symbol
NUDT14
RNA class
mRNA
Alias
Nudix Hydrolase 14 UGPP Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 14 Uridine Diphosphate Glucose Pyrophosphatase NUDT14 UDPG Pyrophosphatase UGPPase Nucleoside Diphosphate-Linked Moiety X Motif 14 Uridine Diphosphate Glucose Pyrophosphatase UDP-Sugar Diphosphatase Nudix Motif 14 EC 3.6.1.45
Location (GRCh38)
14:105172937-105181323
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_177533.5
Sequence length
854.0 nt
GC content
0.6569

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-392.60 kcal/mol
Thermodynamic ensemble
Free energy: -408.61 kcal/mol
Frequency: 0.0000
Diversity: 275.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((.(((...((((((((((((((....)).))))).).)))))).))).))(((((.(((((((.((((.((.((((((.(((((((((((((((.((.(.((.....)).))).))))))).((((..((.((((((((((((((((((.(((((((.....(((((.((((((((((.((((.((((((.....))))).).))))((.((((((((....))))..)))).))........((((((...)))))).)))))...))))).)))))..))))).)).).)))...))))))))))..)))).))..)))).((((..(((...)))..)))).))))))))...))).(((......)))...))))))))).))))))))))))...(((((((((...((((((((((...(.((((((.(((((((((((.(((...))).)..(((((...(((..(((((.(....))))))..))))))))...((((((.((((((((((((.(((.((((((((.((.....)).)))))))))))...))))(((....)))))))......)))).)))))).((((((((((((((((((((.((((((.(((((..((((((((.((.((....))))(((((((((......)))))).)))..(((((((...((.....))...)))).)))..)))))))).)))))..)))))).))))...))))))).))))))))))))))))))).)))))).)(((....)))(((((....)))))..............)))))...........))))).)))))))))..
Thermodynamic Ensemble Prediction
.,,{{{(((({...((((((((((((,(,...)).))))).}.)))))).|||||||(,({{(((((({.({((,(({(((.(({({{{{{,||||{|||,|{.{.||,,...}),.))})}))}))|{(((,.((.(({(((((((((((((((.(((((((.....(((((.((((((((((,(((({,(((((.....))))).},|},|{..,((((,,,...}))).}})))),,.........((((((...)))))).}))))...))))).)))))..))))).)).).)))...))))))))))).)))}.)}..}||},((((..{,{...|||..}}}).}}}}}}}),,.}||.{{{,..,,.|}}|,,)}}}))))}.})}||||||}},,..((({(({({((,(((((({(((,..,.((((((.(((((((((((.....,,{{{.|,,{,|||}}}|{|}|({(,(.({{{,,}}},)}}))}})))}...((((((.((((((((((((.((,(((((((((.((.....)).)))))))))}}...)))}{{{....}},)))),.....}))).)))))).,(((((((((((((((((((.((((((,(((((,.(((,{((({({,{|.,||}}},{{({(((((......)))))).)))..{((({((,,.{{.....||,|.,}}).))).,}}}})))),))}}},,)))))).)))),..})))))),})))))))))))))))))).)))))).}||,..,,.))||||,....})))),}},,.,,},,.,})))))),,,}.......)))}.)),}}))))..

Transcripts

ID Sequence Length GC content
NM_001318380.2 NCBI
AGAGCCGCGGUCACGCGCCCGCCCGAAGGCUCCUGUCGGGACAGGGCGC… 1031 nt 0.6528
NM_177533.5 NCBI
AGAGCCGCGGUCACGCGCCCGCCCGAAGGCUCCUGUCGGGACAGGGCGC… 854 nt 0.6569
Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Forensic Context

A study in humans identified a molecular signature of chronic cocaine abuse in postmortem midbrain dopamine neurons, with the transcript for the NUDT14 being downregulated -1.4-fold in cocaine abusers and performing as a diagnostic biomarker in subject classification [Bannon et al. DOI:10.1038/Npp.2014.70].