Basic Information

Symbol
NUDT7
RNA class
mRNA
Alias
Nudix Hydrolase 7 Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7 Peroxisomal Coenzyme A Diphosphatase NUDT7 Nucleoside Diphosphate-Linked Moiety X Motif 7 Nudix Motif 7 EC 3.6.1.77 EC 3.6.1.-
Location (GRCh38)
16:77722485-77742260
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001105663.3
Sequence length
1096.0 nt
GC content
0.4316

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-290.80 kcal/mol
Thermodynamic ensemble
Free energy: -311.37 kcal/mol
Frequency: 0.0000
Diversity: 332.43
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((....))).....(((.((.((((....))))..)).)))......(((((((....)).)))))...((((.((.((((....))))))))))........(((.(.((((((((..((((((.((((....)))).......(((((((((..........)))))..(((((((((......(((((((((((....))))...))))))).......))))))))).........((((((((..((((.(((((((((((((........(((((((.((((....((((.(.((.........)).).))))(((....))))))))))))))))))).((((((((((((.....(((((.(((((((.((((((.........(((.((........)).))).........))))))))))))))))))......))))).).)))))).)))))......(((((..........)))))...))).))))..)))))))).....((((......))))))))..(((((((((.(((((....((((((((((((((((.....(((......)))..............))))))))...........))))))))...)))))((((...))))))))))))))))))))))))))).).)))........((((((.(((...(((((..((.....(((((....)))))....)).)))))...)))))))))((((((....(((...)))...)))))).....))))))......(((((((((......((((..(((((((((((((((((.........(((((........)))))...(((((..(((.....(((((((((.((((((.((((((.(((............))).))))))....))))))..)))))))))...)))..)))))..((((((.(((((..........)))))))))))......(((((((((.((.....)).))).))))))......)))))...))))))))).))).)))).....)).))))))).........
Thermodynamic Ensemble Prediction
(((((({(,.,,|}}|,{{{{(,({((,(({{...{||||..{((((({{.......|}}}...)))},,|||...((({{((,((((....)))))))))).,.....,|||||{{((,{(((|{((({{{.{|{|....,}}}.|,,,..|{{,(((((..........)))))..{{{{{{{{{..,...(((((({((((....))))...)))))))..,,,,,,}}}))))),,...,},,|||(((((..{(({.{((((((((((((........(((((((.((((....((((.(.((.........)).).)))){((....))))))))))))))))))).((((((((((((.....((((,{((((((,,((((((.,.{{.(({,{,.{{,,......}).))))).,,,,..))))))))))))))))))......))))).),}))))).|||}|.|,.,.(((((..,.......}|||}....}}.)))},,)}}})))).....{{{(......}}}},|,...(((((((({.(((((..,.((((((((((((((((.....(((......}))..............))))))))}..........}))))))),..)))))((({...}))))))))))))))))},|||||||.,({,.......,|||...,{|{||||......,}))}})}.(((({....))))){{{{|..(((((((.((((..|(({,.......,}||,,...))))..)))))))..))))),...,,.,,,,{{|,,.,}}.,((((|{{{{(,,,,(((,((((,((((({.,,..,...,..{{.({{(({,....}}}}}|,}}.|...,,||,}}|}|||}}}.))),.})))))}}})),,}|||}}}}}},.}},|,,}}}}}},||||,.,||,...||,,{|||....{({{{(.((({{.,|,.,},..}}}}}}}}}}}......|{|||{,{|.,{.....}|.}}}.}}}}}}.....,)))}}..,)))}}})))..))))))}.....}}.,)))))),........

Transcripts

ID Sequence Length GC content
NM_001105663.3 NCBI
GCUCUGCGCAAGCGCGACCGACCGAGCAGCUCCGAGGAGUCCGCCCGGA… 1096 nt 0.4316
NM_001243657.2 NCBI
GCUCUGCGCAAGCGCGACCGACCGAGCAGCUCCGAGGAGUCCGCCCGGA… 1190 nt 0.4429
NM_001243660.2 NCBI
GCUCUGCGCAAGCGCGACCGACCGAGCAGCUCCGAGGAGUCCGCCCGGA… 1051 nt 0.4253
NM_001243661.2 NCBI
GCUCUGCGCAAGCGCGACCGACCGAGCAGCUCCGAGGAGUCCGCCCGGA… 937 nt 0.4098
Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Forensic Context

A study in mice demonstrated that the NUDT7 gene exhibited differential regulation in the primary somatosensory cortex depending on the pain model, being downregulated after formalin-induced inflammatory pain but upregulated following burn injury [Erdei et al. DOI:10.3390/ijms26083538].