Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within neuron fate commitment. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in mice demonstrated that perinatal lead (Pb) exposure was associated with a 12.4% increase in oligodendrocytes in the adult hippocampus and altered gene expression in specific cell clusters [Bakulski et al. DOI:10.1093/toxsci/kfaa069].