Armadillo Repeat Containing X-Linked 1
ALEX1
GASP7
ARM Protein Lost In Epithelial Cancers On Chromosome X 1
Armadillo Repeat-Containing X-Linked Protein 1
Arm Protein Lost In Epithelial Cancers, X Chromosome, 1
Protein ALEX1
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]
Forensic Context
A study in humans identified the ARMCX1 as a hub gene in the sky-blue co-expression module of platelets from ST-segment elevation myocardial infarction (STEMI) patients, where it was associated with functions related to cell membrane signal transduction [Zhang et al. DOI:PMC8129354].