Basic Information

Symbol
OXT
RNA class
mRNA
Alias
Oxytocin/Neurophysin I Prepropeptide OT-NPI OXT-NPI OT Oxytocin, Prepro- (Neurophysin I) Oxytocin, Prepropeptide Oxytocin-Neurophysin 1 Neurophysin I Oxytocin-Neurophysin I, Preproprotein Oxytocin
Location (GRCh38)
20:3071620-3072517
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000915.4
Sequence length
513.0 nt
GC content
0.6784

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-216.30 kcal/mol
Thermodynamic ensemble
Free energy: -224.68 kcal/mol
Frequency: 0.0000
Diversity: 118.39
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((......))..(((((...(((((((...((.(((.(((((((..((((.......))))...)).)))))...))).))........((((.((......))...(((((((.(((..(((.((((((.((((((........)).))))..)).))))...)))..))).))))))).)))).((.((((((((((((......((.((.(((.....))).)).))....)))))....)))))))))))))))))))))(((((((..((((((.(((((((((((.....)).)))..)))).))((((((((((((((((((((((.....(((.(((((((((((..((.((((......)))).))..).)))))..))))).)))........)).))))......((((.((.........)).)))))))).))).)))))))))........((((........)))).............))))))..)))))))...
Thermodynamic Ensemble Prediction
.,,.,,,..,)..,((((...(((((((..,((.({{.(((((((..((((.......))))...)).)))))...}||,|}.,......((((.,,.....,|}...{((((((.(((..(((.({((,{.((((((........)).))))..},|)))}...)))..))).))))))}.}))},{{.((((((((((((......((.((.(((.....))).)).))....)))))....))))))))})))))))))))|(((((((..((((((.{{(((((((((.....))},))..)))),|,((((((((((((((((((((((....{(((.((((({(((((..((.((((......)))).))..),))))}..))))).))).,.....,),.))))......,,{,.|{,,.{{,...,}.))),)))).))).))))))))),.......((((........)))).............))))))..)))))))}..

Transcripts

ID Sequence Length GC content
NM_000915.4 NCBI
ACCAGUCACGGACCCUGGACCCAGCGCACCCGCACCAUGGCCGGCCCCA… 513 nt 0.6784
Summary

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Forensic Context

No relevant information is available at the moment.