This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Forensic Context
A study in humans demonstrated that the PCBP3 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption in postmortem prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159].