Enables chromatin binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in mice demonstrated that the PCLAF is a marker for cycling myeloid cells and is upregulated in a neutrophil-like monocyte cluster (C9) enriched following clodronate pre-treatment and controlled cortical impact brain injury, correlating with a proliferative phenotype and neuroprotective outcomes including reduced lesion volume and improved cerebral blood flow [Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8]. In human skin wound healing, the PCLAF is identified as a marker for cycling myeloid cells [Liu et al. DOI:10.1016/j.stem.2024.11.013].