Basic Information

Symbol
PCP4
RNA class
mRNA
Alias
Purkinje Cell Protein 4 PEP-19 Calmodulin Regulator Protein PCP4 Brain-Specific Polypeptide PEP-19 Brain Specific Polypeptide PEP19 Brain-Specific Antigen PCP-4 PEP19
Location (GRCh38)
21:39867438-39929397
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006198.3
Sequence length
534.0 nt
GC content
0.4419

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-127.30 kcal/mol
Thermodynamic ensemble
Free energy: -137.98 kcal/mol
Frequency: 0.0000
Diversity: 80.29
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((...(((..(.(((((((..((((((...(((((((((.(((((.((....)))))))....(.((((......)))).)(((.(((..((.(............(((((((....(.(((..(((....((((((.....))))))....))).))).)...))))))).........).))..))).))).))))))))).)))))).......))).)))).)..))))))))((((....(.((((((......)))))).)....))))..........((((..((((.(((....))).......(((..((((...((((((.((((.....((.(((((((((.(((.((((.(........).)))).)))((((....))))....((((((((.((....)).))))))))...))).)))))).)).))))..))))))))))..)))....(((((((.....((((((.(((......)))))))))....)))))))....))))..))))
Thermodynamic Ensemble Prediction
...(((((...(((..(.(((((((.,((((((...(((((((({,(((((.((....))))))).,,{({,((.{{..{.||||{{{,,.,||,.{(..............(((((((....{.(((..(((....((((((.....))))))....))).))).}...))))))).........,})).},)).)))}))))))))).)))))).......))),,))).)..))))))))((((....{.((((((......)))))).}....))))..........{(((.,((((.(((....))).......(((..((((...((((((.((((.....((.(((((((((.,{{.((((.(........,.)))).))|((((....)))),...((((((((,((....,),))))))))...)))},))))).)).))))..)))))))))),,)}}....{((((((.....((((((.(((......)))))))))....))))))}....)))).,)))}

Transcripts

ID Sequence Length GC content
NM_006198.3 NCBI
AGCGACCCCUGAGCAGUGUUCUCUGUGCUGAGCGGCGGGACUGAGCUGU… 534 nt 0.4419
Summary

Enables calcium ion binding activity and calmodulin binding activity. Involved in positive regulation of CAMKK-AMPK signaling cascade and positive regulation of neuron differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Biomarker of Huntington's disease and leiomyoma. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Sprague-Dawley rats demonstrated that the PCP4 gene exhibited a biphasic upregulation in the spinal cord at 3 and 7 days post-tibial fracture, followed by downregulation at 14 days, a temporal pattern validated by qRT-PCR [Deng et al. DOI:10.1038/s41598-025-17561-6]. A study in rats demonstrated that Purkinje cell protein 4 mRNA was differentially expressed in the hypothalamus, with 92 tags in control samples versus 34 tags in hypothermic samples, and this higher expression in control hypothalami was validated by quantitative PCR [Takamiya et al. DOI:10.1016/J.Jflm.2012.04.017].