Basic Information
Symbol
PDE9A
RNA class
mRNA
Alias
Phosphodiesterase 9A
High Affinity CGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A
CGMP-Specific 3',5'-Cyclic Phosphodiesterase Type 9
Phosphodiesterase PDE9A21
EC 3.1.4.35
HSPDE9A2
Location (GRCh38)
21:42653591-42775513
Forensic tag(s)
Cause of death analysis
MANE select
Transcript ID
NM_002606.3
Sequence length
2192.0 nt
GC content
0.5502
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 2012 nt | 0.5427 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1863 nt | 0.5389 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1808 nt | 0.5398 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 2033 nt | 0.5401 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1941 nt | 0.5420 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1819 nt | 0.5388 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1999 nt | 0.5473 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1934 nt | 0.5398 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1764 nt | 0.5397 | |
| GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… | 1723 nt | 0.5421 |
Showing 1 to 10 of 21 entries
Summary
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Forensic Context
A study in human patients with severe heat stroke demonstrated that serum exosomes contained significantly increased expression of the PDE9A mRNA, which was associated with the blood coagulation pathway [Li et al. DOI:10.3389/fimmu.2021.624753].