Basic Information

Symbol
PDE9A
RNA class
mRNA
Alias
Phosphodiesterase 9A High Affinity CGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A CGMP-Specific 3',5'-Cyclic Phosphodiesterase Type 9 Phosphodiesterase PDE9A21 EC 3.1.4.35 HSPDE9A2
Location (GRCh38)
21:42653591-42775513
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002606.3
Sequence length
2192.0 nt
GC content
0.5502

Transcripts

ID Sequence Length GC content
NM_002606.3 NCBI
GAGCGGAGGAGACCCUGCGGCGCGCGGCGGCGGCUCCCGGGCGUCCCGG… 2192 nt 0.5502
Showing 21 to 21 of 21 entries
Summary

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human patients with severe heat stroke demonstrated that serum exosomes contained significantly increased expression of the PDE9A mRNA, which was associated with the blood coagulation pathway [Li et al. DOI:10.3389/fimmu.2021.624753].