Basic Information

Symbol
PDGFC
RNA class
mRNA
Alias
Platelet Derived Growth Factor C Fallotein SCDGF Spinal Cord-Derived Growth Factor Platelet-Derived Growth Factor C PDGF-C VEGF-E Secretory Growth Factor-Like Protein
Location (GRCh38)
4:156760454-156971799
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016205.3
Sequence length
4570.0 nt
GC content
0.4365

Transcripts

ID Sequence Length GC content
NM_016205.3 NCBI
ACCCCGUGCGGAGACGCCGCGCGUAGCCCCGAGGUUAGCGCGGAGCCCG… 4570 nt 0.4365
Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Forensic Context

A study in humans demonstrated that platelet PDGFC mRNA expression was negatively correlated with platelet aggregation to ADP in patients with acute myocardial infarction [Eicher et al. DOI:10.3109/09537104.2015.1083543].