Basic Information

Symbol
PDGFD
RNA class
mRNA
Alias
Platelet Derived Growth Factor D SCDGF-B IEGF MSTP036 Spinal Cord-Derived Growth Factor B Platelet-Derived Growth Factor D Iris-Expressed Growth Factor SCDGFB PDGF-D Spinal Cord Derived Growth Factor B
Location (GRCh38)
11:103907189-104164379
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_025208.5
Sequence length
3838.0 nt
GC content
0.3942

Transcripts

ID Sequence Length GC content
NM_025208.5 NCBI
ACCAUUUAUCAGCUCAGCACCACAAGGAAGUGCGGCACCCACACGCGCU… 3838 nt 0.3942
NM_033135.4 NCBI
ACCAUUUAUCAGCUCAGCACCACAAGGAAGUGCGGCACCCACACGCGCU… 3820 nt 0.3937
Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human menstrual blood-derived stem cells (MenSCs) identified the PDGFD as a differentially-expressed gene down-regulated with increasing passage number, associating it with functions in cell migration, proliferation, and anti-apoptosis [Chen et al. DOI:PMC4713568].