Basic Information

Symbol
PDK2
RNA class
mRNA
Alias
Pyruvate Dehydrogenase Kinase 2 PDHK2 [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 2, Mitochondrial Pyruvate Dehydrogenase Kinase, Isoenzyme 2 Pyruvate Dehydrogenase Kinase, Isozyme 2 PDH Kinase 2 EC 2.7.11.2 PDKII Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 2, Mitochondrial Pyruvate Dehydrogenase Kinase Isoform 2 EC 2.7.11
Location (GRCh38)
17:50094737-50112152
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002611.5
Sequence length
3364.0 nt
GC content
0.5966

Transcripts

ID Sequence Length GC content
NM_001199898.2 NCBI
CUUUUCCUGAGCCGCUUGGAUCUUUGUGGAAGCGGGUGGGCUGCAUAUA… 3478 nt 0.5903
NM_001199899.2 NCBI
UAAUGGGGAAGCAGGAACCGGCCGGGGCCUCUCGACGGGGCUGCUGAUG… 3277 nt 0.5920
NM_001199900.2 NCBI
GGCGGCCGAACCGCGUCGCUGGGCCGAAAGGUGCGCGAGCGCUGCCCGC… 904 nt 0.5553
NM_002611.5 NCBI
GGCGGCCGAACCGCGUCGCUGGGCCGAAAGGUGCGCGAGCGCUGCCCGC… 3364 nt 0.5966
Summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Forensic Context

No relevant information is available at the moment.