Basic Information

Symbol
PDLIM7
RNA class
mRNA
Alias
PDZ And LIM Domain 7 ENIGMA PDZ And LIM Domain 7 (Enigma) PDZ And LIM Domain Protein 7 Protein Enigma LMP Lim Mineralization Protein 3 LIM Mineralization Protein LIM Domain Protein 1110003B01Rik LMP1 LMP3
Location (GRCh38)
5:177483393-177497608
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005451.5
Sequence length
1712.0 nt
GC content
0.6454

Transcripts

ID Sequence Length GC content
NM_005451.5 NCBI
GUCAGAACACUGGCGGCCGAUCCCAACGAGGCUCCCUGGAGCCCGACGC… 1712 nt 0.6454
NM_203352.3 NCBI
GUCAGAACACUGGCGGCCGAUCCCAACGAGGCUCCCUGGAGCCCGACGC… 1610 nt 0.6373
NM_213636.3 NCBI
GUCAGAACACUGGCGGCCGAUCCCAACGAGGCUCCCUGGAGCCCGACGC… 1008 nt 0.6597
Summary

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Forensic Context

A review of forensic proteomics literature notes that the PDLIM7 is a protein marker for post-mortem interval (PMI) estimation in early PMI from skeletal muscle, where its abundance decreases post-mortem [Alex et al. DOI:10.1016/j.scijus.2025.101320].