Basic Information

Symbol
PDPK1
RNA class
mRNA
Alias
3-Phosphoinositide Dependent Protein Kinase 1 PDK1 3-Phosphoinositide-Dependent Protein Kinase 1 EC 2.7.11.1 3-Phosphoinositide-Dependent Protein Kinase 2 Pseudogene Putative 3-Phosphoinositide-Dependent Protein Kinase 2 PkB Kinase Like Gene 1 PkB Kinase EC 2.7.11 PRO0461 PDPK2P PDPK2 HPDK1
Location (GRCh38)
16:2537978-2603190
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002613.5
Sequence length
7184.0 nt
GC content
0.5159

Transcripts

ID Sequence Length GC content
NM_001261816.2 NCBI
AUUGCUGGGGCUCCGCUUCGGGGAGGAGGACGCUGAGGAGGCGCCGAGC… 6973 nt 0.5191
NM_002613.5 NCBI
AUUGCUGGGGCUCCGCUUCGGGGAGGAGGACGCUGAGGAGGCGCCGAGC… 7184 nt 0.5159
NM_031268.6 NCBI
AUUGCUGGGGCUCCGCUUCGGGGAGGAGGACGCUGAGGAGGCGCCGAGC… 6803 nt 0.5211
Summary

Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signaling cassette; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human forensic autopsy cases using RNA sequencing demonstrated that transcripts for the PDPK1 were markedly upregulated in a case of fatal insulin overdose compared to control cases, indicating activation of the insulin receptor substrate–PI3K–PDK1/2 axis [Nakao et al. DOI:10.1016/j.legalmed.2025.102772].