Basic Information

Symbol
PDPN
RNA class
mRNA
Alias
Podoplanin Aggrus PA2.26 T1A-2 D2-40 Gp38 GP40 Lung Type I Cell Membrane Associated Glycoprotein Glycoprotein 36 PA2.26 Antigen T1-Alpha GP36 T1A Lung Type-I Cell Membrane-Associated Glycoprotein (T1A-2) Glycoprotein, 36-KD HT1alpha-1 HT1alpha-2 HT1A-1 OTS8 T1A2 TI1A Gp36
Location (GRCh38)
1:13583465-13617957
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006474.5
Sequence length
2737.0 nt
GC content
0.4731

Transcripts

ID Sequence Length GC content
NM_001006624.2 NCBI
CCUUUUUGGCGAGACAAUGUGCAAAUGACACCGUUUUGUGCUCACCAGG… 2648 nt 0.4588
NM_001006625.2 NCBI
CCUUUUUGGCGAGACAAUGUGCAAAUGACACCGUUUUGUGCUCACCAGG… 2642 nt 0.4587
NM_001385053.1 NCBI
CCUUUUUGGCGAGACAAUGUGCAAAUGACACCGUUUUGUGCUCACCAGG… 2717 nt 0.4575
NM_006474.5 NCBI
AACUGCAAAGUUUGCUGUCCGGCUGCCUAGGGUCUGGGAAGCUCGGGCA… 2737 nt 0.4731
NM_198389.2 NCBI
AGACCACCUUGCGGCCGACCCCGCUCCCCCGCCUCCUCGGGAGAGAUAA… 2822 nt 0.4748
Summary

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats using single-cell transcriptomic analysis of radiation-induced lung injury identified numerous orthologous genes associated with inflammatory processes, including the PDPN which was characterized as a smooth muscle cell marker expressed in two subpopulations of smooth muscle cells (artSMC and non-artSMC) [Shi et al. DOI:10.17305/bb.2024.10357]. In human dermal lymphatic endothelial cells, podoplanin (PDPN) was utilized as a lymphatic-specific marker for fluorescence-activated cell sorting and qPCR validation in research investigating lineage-specific lncRNAs [Ducoli et al. DOI:10.1038/s41467-021-21217-0].