Basic Information

Symbol
PF4
RNA class
mRNA
Alias
Platelet Factor 4 SCYB4 CXCL4 Chemokine (C-X-C Motif) Ligand 4 C-X-C Motif Chemokine 4 Oncostatin-A Iroplact PF-4
Location (GRCh38)
4:73980811-73982027
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002619.4
Sequence length
773.0 nt
GC content
0.4398

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-211.20 kcal/mol
Thermodynamic ensemble
Free energy: -227.74 kcal/mol
Frequency: 0.0000
Diversity: 184.21
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((.(((((...(((..(((........)))..)))((((.........))))(((.(((((((....))).)))))))((((..(((.((((.((((..((((((((((((.((.....(((((....))))).......(((((((.(((((..((((......))))..)))...)).)))).)))(((((((.(.(....((((........))))...)))))))))..)).)))))))).))))....)))))))).))).))))....((..(((.((..((((...)))).))..)))..)).......(((((......)))))...(((.(.(((((...............))))).).)))(((((...))))).......((((((............))))))...((((((((((((.......))))).))))))).)))))..(((((((((((.....((((((..............))))))..(((((.(((.((.((........)).)).))).)))))(((((((..((...))..)))))))...((((........))))(((((((...(((((..(((...(((.((.(((.(((((((.((((((((..((.(((..(((((..(((((.......))).))....)))))...))).))...))))))))..))))))))))..)).)))....))).)))))....))))))).))))))))))))))).........
Thermodynamic Ensemble Prediction
...(((({((({{..{(((,.,((,,,{{...,}|,.,,},||,..}.,,,.,})))||.{(((((((....))).)))))}}((((..(((,((((.((((..((((((((((((.(({.(((((((,.,..||,,,.}},{{.{((((((.(({((..((((......))))..)}}},.)).)))).)))|||((((.(.({{..,,,|}}....}}))},..,)))))).))}.,,.)))))))).))))....)))))))))))..))))....{{..(((.{(..((((...)))).}}..)))..)}.....,.{((((.....,|}}}}...}||}|.||||..............,,}},||{.,{(|{(({,.}}})))}}},....((((((............))))))...((((((((((((.......))))).))))))}.,,|||{{(((((({{{{{...,.((((((..............}}}}}}.,,,,,.......((((((((((({{{{,....(((((..(((((((..((...))..)))))))..,((((........))))})))))}}}}}....))))))))))).{(((((((..((((.((((({.....((((....((({,(((((,{{,.{{,{(((({,....,}))}.}).}))).....)))))))))...)))).}))))).))))..))))))}.},.,}}}}})))}),}}}}}}},))))).........

Transcripts

ID Sequence Length GC content
NM_001363352.1 NCBI
AUCUUAGUUUCCGCACCGCAGUUCCUCGGUGUCCACUUCAGGCUUCCGG… 1061 nt 0.4892
NM_002619.4 NCBI
AUUGGCCACAGAGACCCAGCCCGAGUUUCCCAUCGCACUGAGCACUGAG… 773 nt 0.4398
Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

Forensic Context

A study in human burn patients demonstrated that the PF4 mRNA transcript is associated with a prothrombotic state and is upregulated within the first 7 days following thermal injury [Misganaw et al. DOI:10.1093/jbcr/iraf012].