Basic Information

Symbol
PFDN5
RNA class
mRNA
Alias
Prefoldin Subunit 5 PFD5 MM-1 MM1 C-Myc-Binding Protein Mm-1 C-Myc Binding Protein Myc Modulator-1 Myc Modulator 1 Prefoldin 5
Location (GRCh38)
12:53295291-53299452
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002624.4
Sequence length
596.0 nt
GC content
0.5050

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-191.80 kcal/mol
Thermodynamic ensemble
Free energy: -203.60 kcal/mol
Frequency: 0.0000
Diversity: 173.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((......))).((.((((.(.(((((((...((((..((((((((((((((((((...(((........)))........((((((..(((.....)))(((((((.(((.(.((..((((((.......(((.((.(((((..(((...(((...)))...)))))))).))..)))......)))))).)).)))))))))))(((((((.....)))))))((((((((.((.(((((....((((((((((.(.(.....).).)))).))))))...))))).)))))))))).....)))))).((...))..(..((((((((((((.......((((((((..(((......))))))))))).......)))))..)))))))..)(((........)))((((((....)))))).......)))))))))(((.(((.((((.(((((...((((((((........))))))))..(((((((.........)))))))....))))).)))))))))))))..)))))).....(((.(((.....))).)))))))..)))))))).)))).))..
Thermodynamic Ensemble Prediction
....,{(,.....}|{,({.((({...{||{{{{,.,,.{{..|{{,,{||||{{{..((({{,,(({{{.,.,.,||.{{{{|.{(,,((..((((((((((..(((((((.(((.(.((..((((((.,.,,..{((,((.(((((..(((...(((...)))...)))))))).)).}))),,....)))))).)).))))))))))){((((((.....))))))}((((((((.((.(((((....((((((((((.(.,.....,.).)))).})))))...))))).)))))))))).....,||{|{.|{,.,|,..{,.(((((((,{{{(,..,...((((((((..(((......))))))))))).......))))},.)}})}}}{{{(((......,.|||((((((....)))))|{|||....)}}))|{|||||{,{,(((({{{{|{,..({{{{{{|.,,.,...))))))}).,|,,{|||.....,,..}||{{{{{...)))))}))))))))))))))))),,},}}..}),})}}}.}}.,}...||||.....))}))})),)))),)),.

Transcripts

ID Sequence Length GC content
NM_002624.4 NCBI
CUCUUCGUUAAGUCGGCCUUCCCAACAUGGCGCAGUCUAUUAACAUCAC… 596 nt 0.5050
NM_145897.3 NCBI
CUCUUCGUUAAGUCGGCCUUCCCAACAUGGCGCAGUCUAUUAACAUCAC… 461 nt 0.5076
Summary

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human keratinocytes and mouse skin demonstrated that X-ray irradiation (5 Gy) significantly altered gene expression, with the PFDN5 being upregulated 1.54-fold 3 hours post-irradiation [Koike et al. DOI:10.1269/jrr.46.173].