Basic Information

Symbol
PGAM2
RNA class
mRNA
Alias
Phosphoglycerate Mutase 2 PGAM-M Muscle-Specific Phosphoglycerate Mutase Phosphoglycerate Mutase 2 (Muscle) Phosphoglycerate Mutase Isozyme M BPG-Dependent PGAM 2 PGAMM EC 5.4.2.11 EC 5.4.2.4 EC 5.4.2.1 GSD10
Location (GRCh38)
7:44062727-44065605
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000290.4
Sequence length
837.0 nt
GC content
0.6225

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-336.40 kcal/mol
Thermodynamic ensemble
Free energy: -349.48 kcal/mol
Frequency: 0.0000
Diversity: 209.05
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((.((((....))))((((((.(((((...(((((((..(((.(((..(((.((...)))))..))).))).)).)))))..(((((((..(((....(((((.(((((((...(((.((((((((.....((.(((..((.((((..((.....))...)))).))..)).).)).(((((........)))))....))).))))).)))...))))))).))))).....)))..).)))))).))))).))))))(((((.(((...((.(((((.......))))).))...))).))))))))))))).((((.(((((...(..(((((..((((((.(((.(((((((((((.((((((..((.(((.((..((((...((((((((((....((.......(((((...((.(((.((((((..((((........)))).)).)))).((((((.((...(((((((..........(((((((((((((..........(((((..((((.((..((...(((((((.....)))))))..))..)).)))))))))..))).)))).))))))))).))))..))))))))))))).)))))........))..)))))))).))...)))).))..))).))..)))))))).......)))))....((((((.(((......((.((....))))....))).)))))).(((((.(....).)))))...))))((....)).))).))))))..)))))..)....)))))..))))((((.((((((.........)))).)).)))).....
Thermodynamic Ensemble Prediction
((((((((.((((....))))((((((.((((((({..((((((.{,{.,,(,,{((,{{((,{{|||||||||}}}.)}.{{{,(((((((,{{..{{,..,,|,|||}||||||,}}}{{{.{{{{{{{{....{({,{((..{(.((((..({,,...}),..)))).))..)).).)).(((((........))))),,,.)}).))})),))}..,)))))))})))},.....,})}})}),,))).))))).))))))(((((.(((...((.(((((.......))))).))...))).))))))))))))){((((.(((((...(..(((((..((((((.(({.(((((((((((.((((((..((.((({{{..((((...((((((((((.{{{{{{{{{{{{{,{{{,..{,.,,,,|,||....((((........))))}))}))},{((((({,((...(((((((.....,,...(((((((((((((..{{...}}.(((((..((((.((..{{,,.(((((((.....)))))))..)),.)).)))))))))..))).)))).))))))}}}.))))..))))))))))))}.,|||,..}}....))..)))))))).))...)))).)).}))).))..)))))))).......)))))....{(((((.(((......((.((....))))....))).)))))},(((((.{....}.))))}.},))))|{..,})).))).))))))..)))))..,,...)))))..))))|(((.((((((.........)))).)).)))).....

Transcripts

ID Sequence Length GC content
NM_000290.4 NCBI
GUCCCCGUCCAGAGUCCUCUGUGGUCCCUGCUGCCACCAUGGCCACUCA… 837 nt 0.6225
Summary

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Forensic Context

A study in rats demonstrated that in a model of acute right heart failure induced by pulmonary artery banding, the PGAM2 was identified as a protein with more interactive evidence in the right ventricle versus left ventricle protein-protein interaction network [Cao et al. DOI:10.1177/2045894019879396].