Basic Information

Symbol
PGLYRP1
RNA class
mRNA
Alias
Peptidoglycan Recognition Protein 1 PGRP-S PGRP TNFSF3L PGLYRP PGRPS TAG7 TNF Superfamily, Member 3 (LTB)-Like (Peptidoglycan Recognition Protein) Peptidoglycan Recognition Protein Short Peptidoglycan Recognition Protein
Location (GRCh38)
19:46019153-46023053
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005091.3
Sequence length
708.0 nt
GC content
0.6201

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-285.00 kcal/mol
Thermodynamic ensemble
Free energy: -295.36 kcal/mol
Frequency: 0.0000
Diversity: 125.79
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((...))))).(((((.(((.(((((.(((.(((..((.(((((((((..(((((((((((((..((((..(((((...))))).))))..))))).....).)))))...)).)))))...)))).))..))).)))))))).)))...)))))((((.((((.....))))))))(((.((((.....((((((((((((...(((((...(((((.((.((((...(((.........))).)))).))..)))))...)))))...))))))))))..)).....)))).)))))....(((((((((.(((....((((((((((((((.((((....))))((((((((..((........((((((....((((.......((((....))))((((((.(((....)))..)))))).......(((((.(((((.(((((((.(((((((((((((...))).))).....))))))).)))))))((((((....))))))((((...............))))...(((((((((...))))).))))....(((.....)))....))))).))))).....((((.((.............)).))))...))))...)))))).........))..))))))))..........))))))...)))))))).))).)))))))))...
Thermodynamic Ensemble Prediction
.({(((((...))))).{((((,(({.(((((.(((.(((..((.(((((((((..((({(((((((((..((((..(((((...))))).))))..))))}.....).))))),..},.)))))...)))).))..))).})}))))).|||...,|||,((((.((((.....))))))))|||.{{|{...,,|(((((((((((...(((((...(((((.((.((((,..({{.........))).)))).))..)))))...)))))...)))))))))),..).,...)))).))}))....(((((((((.(((....((((((((((((((,((((....))))((((((((..((........((((((,,....,||...|..,{|{....},,|((((((.(((....)))..))))))}.......((((,((({(,(((((((.(((((((((((((...))).))),....})))))).)))))))(((((({{{{||||}|((((......,........))))..,|||{(((((...))))).}}}}....(((.....)}},...||}}|,,.,,}},..}||..........)}}},},,))))))},.,}}))}}})))))).........))..))))))))..........)))))}..,)))))))).})).)))))))))...

Transcripts

ID Sequence Length GC content
NM_005091.3 NCBI
AGCGGUCUCCCGGACCCUGCCGCCCUGCCACUAUGUCCCGCCGCUCUAU… 708 nt 0.6201
Summary

Enables several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the PGLYRP1 as a potential diagnostic biomarker for burn injury, where it was significantly up-regulated in patient blood samples and validated as one of twelve key immune-related genes through bioinformatics analysis and qRT-PCR [Niu et al. DOI:10.1093/jbcr/irad050]. Separately, a human study surveying plasma microRNA transcriptomes for acute myocardial infarction mentioned the PGLYRP1 in its introduction as a proposed diagnostic protein reported to be more sensitive and specific for early-stage STEMI than traditional markers, though it was not experimentally studied within that investigation [Wang et al. DOI:10.1186/s40364-024-00690-x].