Basic Information

Symbol
PHGR1
RNA class
mRNA
Alias
Proline, Histidine And Glycine Rich 1 Proline, Histidine And Glycine-Rich Protein 1 Proline/Histidine/Glycine-Rich 1 Proline-Histidine-Glycin-Rich Protein 1
Location (GRCh38)
15:40351033-40356434
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001145643.2
Sequence length
436.0 nt
GC content
0.6261

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-176.50 kcal/mol
Thermodynamic ensemble
Free energy: -185.02 kcal/mol
Frequency: 0.0000
Diversity: 169.80
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.....(((((((((...)).....((((.....)))).((((........)))).((((....))))..)))))))..((((....(((((((((((((........))))).))).(((((.....))))).((((((((((((((..((((((...........))))))))))))))..))))))...((((((((((((((((((((((..((((((...........))))))))))))))).(((.....))).)))))))).))))).......)))))))))...........((((((.((((((...((((.((......(((((..((...))..)))))....)).))))......((......))....))))))))))))........(((((...))))).....)))..........
Thermodynamic Ensemble Prediction
.,......,,,,,{,(({..{{{{{{{(((({....||||.(((({{{{{...,,||{(((({..{|||||.,|||||.{{((((..{{(((((({{(((((........|}}}}.))}{((({{.,,..|||||,|{{|||{(((((({,.{||||,.,,,,,,||..)))},}})}})))).,})))},...{{{||{{{|||{{|{((({(({|.((({{{.....,.,...))))}}})))))))),|||.....))},))))))))))}))).......,,,}},)))}},..}}..,.,|||||}||{|||...||||.,......,|{,{,}}||}}}))..,))),.)}),}.,,||{{{{(.(({{,...,,....,,,,,,,,,,,,........{{{{{...}))))}.}},})},.........

Transcripts

ID Sequence Length GC content
NM_001145643.2 NCBI
AGACUUCCUGCCCCUGCUCUGCACUCUCAGGUAUUCCCUGCUCUUACUC… 436 nt 0.6261
Summary

PHGR1 is a predominantly cytoplasmic protein highly expressed in colon (Oltedal et al., 2018). [supplied by OMIM]

Forensic Context

A study in humans developed a multiplex RT-PCR assay for rectal mucosa identification, where the PHGR1 was positive in 19 out of 19 rectal mucosa samples and demonstrated a positive correlation with ZG16, though it was detected with slight peaks in 2 out of 10 semen samples, with a normalized peak height cutoff set at >0.1 [Akutsu et al. DOI:10.1016/J.Fsigen.2022.102712]. Another comparative study of mRNA-based methods noted the PHGR1 is mentioned in the literature as a useful marker for rectal mucosa [Martin et al. DOI:10.1016/j.fsigen.2025.103297].