Basic Information

Symbol
PHPT1
RNA class
mRNA
Alias
Phosphohistidine Phosphatase 1 PHP14 HSPC141 CGI-202 14 KDa Phosphohistidine Phosphatase Sex-Regulated Protein Janus-A Protein Histidine Phosphatase Protein Janus-A Homolog DKFZp564M173 BA216L13.10 PHP Epididymis Secretory Sperm Binding Protein Li 132P Phosphohistidine Phosphatase 14kDa HEL-S-132P EC 3.9.1.3 EC 3.1.3
Location (GRCh38)
9:136848724-136851039
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014172.6
Sequence length
577.0 nt
GC content
0.6153

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-222.30 kcal/mol
Thermodynamic ensemble
Free energy: -232.07 kcal/mol
Frequency: 0.0000
Diversity: 194.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((((((((((((...((.(((((.(((((.(((.((((((..(((......)))....(((((.(((((((.(.........)))))).)).)))))((.((((..(((((...)))))..)))).))..)))))).)))...........((((..((((((((((.((.((....)))).....(((((...)))))...(((((((((..(((....)))..))))..))))).(((((((((((.............(((((..........))))).(((((..(((....(((((...)))))....)))..)))))...((((......))))......(((..(((.......)))..)))..((((((((...((..(((....)))..))..))))))))))))))))))).))))..))))))...)))).))))).)))))))..))))))))(((((((.(((...))).)).))))))).)))))))(((((((((((((...((((((((((....))))...))))))..)))).......))))))))).....
Thermodynamic Ensemble Prediction
.((((.(({{{((((({(,..{(,(((((,((((({(({.((((((..,{{.{{,,.||,,,,,(((((.(((((((.{.........)))))).)).))))){{.{(((..(((((...)))))..)))}.}}..)))))).,||(((({((.(((,(((.,..((((.,,.....))}},{|{||{,,,.{{{{,..,))))},||{{({(((((..(({....)))..))))..))))),||||,|||,||}.}}}}}}{{{..(((((..........))))).,|||{..((({{,.,,|||}}},}})),,,.)))..))}))}}}}|||...{{{,,...,},..,,...{{{,,.,{,,,.)}.)))}.((((((((...((..(((....)))..))..))))))))|||||||||,..}})))))}.}}}}.}})))}))}}}.,}}||||,.}}}}}}})||||(({.(((...|||{||{||,}}||{,,,,,(((((((({...|)),,)))))}||,,|}}}.)))))..)))|||{.{||.........,))),)))}....

Transcripts

ID Sequence Length GC content
NM_001135861.3 NCBI
AGGGGACUCCGGGAGGAGGAACAUGGCGGUGGCGGACCUCGCUCUCAUU… 632 nt 0.6187
NM_001287342.2 NCBI
AGGGGACUCCGGGAGGAGGAACAUGGCGGUGGCGGACCUCGCUCUCAUU… 583 nt 0.6158
NM_001287343.2 NCBI
AGGGGACUCCGGGAGGAGGAACAUGGCGGUGGCGGACCUCGCUCUCAUU… 635 nt 0.6189
NM_014172.6 NCBI
AGGGGACUCCGGGAGGAGGAACAUGGCGGUGGCGGACCUCGCUCUCAUU… 577 nt 0.6153
Summary

This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Forensic Context

A study in humans demonstrated that a 7-day overfeeding intervention in lean and obese men induced differential expression of 45 genes in abdominal subcutaneous adipose tissue, with the PHPT1 being up-regulated in response to the positive energy challenge [Shea et al. DOI:10.3945/ajcn.2008.25970].