Basic Information

Symbol
PIGF
RNA class
mRNA
Alias
Phosphatidylinositol Glycan Anchor Biosynthesis Class F PIG-F GPI Ethanolamine Phosphate Transferase 2, Stabilizing Subunit GPI Ethanolamine Phosphate Transferase 3, Stabilizing Subunit GPI Ethanolamine Phosphate Transferase, Stabilizing Subunit Phosphatidylinositol-Glycan Biosynthesis Class F Protein GPI11 Homolog Phosphatidylinositol Glycan, Class F OORS
Location (GRCh38)
2:46580937-46617055
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002643.4
Sequence length
1294.0 nt
GC content
0.3895

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-326.90 kcal/mol
Thermodynamic ensemble
Free energy: -351.87 kcal/mol
Frequency: 0.0000
Diversity: 422.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((..(((((((((((((((.((((((..(((((....((((((((((....))))))).))).)))))))).)))..(((((...((((((((((....((((..((......))))))....))))))))))....)))))..........((((.(((((..((((..(((........((((((((.......(((..((((((......)).))))....(((..(((((((...(((((((..................))))))))))))))...))))))......)))))))).........(((((((((((.(.....((((((..........(((((.(((((......(((...(((.((......((((((....))))))..)))))..)))..))))).)))))))))))....).)))))))))))((((((..((((.((..(((.(((((..(((((.......)))))....))))).)))..))))))...)))))).(((((......)))))...(((((....)))))......((((((.........))))))))).))))..)))))))))(((((.(((...))).)))))...)))))..)))))))))).............((((((...((((....((.((((..(((.((...(((((((((((...)))......))))))))..(((..((((((...............(((..(((((((((....))))))))).)))....)))))).))))).)))..))))))..))))....)))))).........((((((((((((((.((.(((((((((((((...))).))))))))......)))).))))).....)))).)))))...((((....(((((...)))))....))))..))))).)))).(((((((...((.(((((((....))))))).)).....((((((((.((.((((.....((((.((((..((......(((((...)))))......))..))))......((((.(((...((((((..((((((.(((........))))))))).)))))).))).))))..(.(((((((............(((((....))))).))))))).)))))......)))).)).))))))))....((((((......(((((...)))))..........(((.(((.((.(((....))))).))))))...))))))...)))))))
Thermodynamic Ensemble Prediction
(((((((((({(((,,,,,,}}})),.((((((,,(((((,.,,,{{(((({{{...,))))))})})}.})))}))).)))..({{{{...((((((((((...,((({,,{(......}}}}}}....})))))))))....}||||,,,.,,...{((((,{{{{{.,(((....,,....}))}|{{{{{{{....,.,|||,.{{{{{{,,..,.))}})))....{(({,({(({{(,,,({(((({,,..{,{{,,...,{{{{|||}||||}}}}}}...,,.,,}......}}||||||.,,,,,...{{{|||||{||,|,.,,,((((((.,,,,.....(((((.(((((......(({,,.{((.({......((((((....))))))..}}})).})))..))))).)))))}}}}}}.,..).)))))))))))|(((((..((((.((..(((.(((((..(((((.......)))))....))))).)))..))))))...)))))}.(((((......)))))...(((((....))))).,....{{((((...,,,,,,}|||}}|||,,|}|{{|}||||,|{(((((.(((...))).)))))}...,,|.,(((({|{{{,,,||,..}}}||..|||},}))},},....|||||}},},}}})}},}}|,.|}}},}}},}})))}}}}}}))))}},)}.||}}..}}}}}.,}.}}}}},.{{((((({{(((((((((....))))))))|((({.,{{|,|.{(((,,{{{{{({..{{((.{(((,....||,,.))..,.)))}.}})),,)))}}}|,{{{.,.(((((((((((...))).))))))))...}},,....,,,..}}}}.}}))}})))},.,||}}}}}}|,{{{...,}}}},...,}},..)))))}}))).{((((({...{{.(((((({....})))))).,}.....{(((((((.{{.((({....,((((,((({..((......{((({,..,}}}}......))..)))}......((((.(((...((((((..((((((.(((.......}))})))))).)))))).))).))))..{,{((({{{.,,,,,.||...,{{||....))},,.})}))))},}}}).....,)))}.}}.))))))))....|||||{......(((((...)))))..........(((.(((.{(.(((....))))}.))))))...,}}))}...)))))),

Transcripts

ID Sequence Length GC content
NM_002643.4 NCBI
CUGGGCCGCCCGUCGUACCUGAUGGUAGGAGGCAGUAGUUCCCCGCUUC… 1294 nt 0.3895
NM_173074.3 NCBI
CUGGGCCGCCCGUCGUACCUGAUGGUAGGAGGCAGUAGUUCCCCGCUUC… 1399 nt 0.3931
Summary

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the PIGF was identified as a single-gene blood biomarker differentiating methamphetamine dependents without psychosis from those with methamphetamine-associated psychosis (MAP) [Breen et al. DOI:10.1038/tp.2016.67]. It was part of a ubiquitin-mediated proteolysis module downregulated in MAP and was validated as a putative MAP biomarker through convergent functional genomic evidence, with a machine-learning classifier achieving 95% accuracy in differentiating the two subject groups.