Basic Information

Symbol
PIP
RNA class
mRNA
Alias
Prolactin Induced Protein GCDFP-15 GCDFP15 GPIP4 SABP Gross Cystic Disease Fluid Protein 15 Secretory Actin-Binding Protein Prolactin-Inducible Protein BRST-2 Prolactin-Induced Protein Apocrine Gp17
Location (GRCh38)
7:143132077-143139739
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002652.3
Sequence length
578.0 nt
GC content
0.4481

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-136.10 kcal/mol
Thermodynamic ensemble
Free energy: -148.78 kcal/mol
Frequency: 0.0000
Diversity: 165.52
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((......)))((((....((.(((((((((..(((.((((((((.((((.(((....)))..)))).)))...(((.(((.(((.(.(((.....))).).))).)))))).......(((((((((...(((.((((..(((.(((.....))).)))..))))..))).....((((.....))))..))).))).))).(((.((((((.....)))))).)))...))))).)))..)))))((((((...((((((((((....(((((((((((....(((...)))....)))..)))).))))...............(((......)))......(((.((((.((....((((...))))....)))))).)))...(((((...(((....))).))))).)))))))))).....................(((((((......)))))))....))))))......))))))..))))(((..((((((..((((....((((.((((......))))..))))..)))).))))))..)))....................
Thermodynamic Ensemble Prediction
.(({......}||({,,...,({{(({{(((((..(((.(((((({{,{{{,,{{{,..{|||,,(((|.,,},,,(((.(((.(((.{.(((.....))).}.))).)))))).......}}}},||||.,,{{{.((((..(((.{((.....))}.)))..))))..}}}..,,.{|||.....|||}..}}}|||{{{|,.{|}}|||(((,....}}}))),,,,..,))))).)))..})))).,{{,,...((((((((((..,,,{{{(((((((....{({...)))....)))..)))).}))}|,{,,..........{{{,,,..,||}......{{{.|{{{.||.,.,((({...})))...,)))))).))}...,,}}}.{{((({{....)})))))})))))))))).....................(((((((......)))))))....}))})},..,,,}||||}..}}},{((..((((((..((((.{{{((({.((((......))))..))))}})))).))))))..}},....................

Transcripts

ID Sequence Length GC content
NM_002652.3 NCBI
ACCACUUCUCUGGGACACAUUGCCUUCUGUUUUCUCCAGCAUGCGCUUG… 578 nt 0.4481
Summary

Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A review of forensic proteomics literature notes that the PIP is a protein marker for donor profiling, specifically showing age-dependent expression changes in oral fluid [Alex et al. DOI:10.1016/j.scijus.2025.101320].