Basic Information

Symbol
PLA2G2A
RNA class
mRNA
Alias
Phospholipase A2 Group IIA PLA2B PLA2L Phospholipase A2, Group IIA (Platelets, Synovial Fluid) Non-Pancreatic Secretory Phospholipase A2 Phosphatidylcholine 2-Acylhydrolase 2A Phospholipase A2, Membrane Associated Group IIA Phospholipase A2 GIIC SPLA2 NPS-PLA2 EC 3.1.1.4 RASF-A PLA2S PLAS1 SPLA2 MOM1 PLA2
Location (GRCh38)
1:19975431-19980462
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001395463.1
Sequence length
846.0 nt
GC content
0.5225

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-252.50 kcal/mol
Thermodynamic ensemble
Free energy: -266.86 kcal/mol
Frequency: 0.0000
Diversity: 177.50
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((.(((((((((......)))))).))).)))((((((.((.((..((((..((((((((((.((((..((((((((((((....(((((((((((((((.((.....))))).))))).(((((((((((.....((((......))))...((((.((((((.((((((((((..(((..(((((.....)))))..(((((((((...))))))))).))))))))))..))).))))))...)))).((((((..(((((.(((...))).)))))....)))))).)))))))))))((.....))...((((((.(((....))).)))))).(((..(((.(((......))))))..))).....)))..)))).....)))))))).((((......)))).....(((((((((.....(((((.....)))))....((((.((.(((..(((.(((.(((((....((((.(((((...(((((((.......)))))))...(((........))).(((((((...............((((((((.....)))))..))).(((....))).....(((((...)))))...)))))))....................................(((((...)))))..((((.....)))).((((..........))))...))))).))))....))))).))).))).....))).))..))))...............)))))))))....))))....))))))))..)).......)))).)))).)))).)))))).........((.....))......
Thermodynamic Ensemble Prediction
.(((,{{(((((((.,,,..}}}}||.||},||}{{({({.{{.{{..(((((,(.((((((({((.(((.(((({{{,...,{.,.,..,|},((((({({|||..,..,)))).))))).(((((((((((.....((((......))))...((((.((((((.(({(((((((..{{{..(((((.....)))))..(((((((((...))))))))).}}})))))))..))).))))))...}))|,(((({,..,{{{..||||,.|,..,),|||||.}})))).)))))))))))(.((((.....)))).)...(((...(((((({((,.{(((((((({.(((((((.((((........))))...))))))).}...{((((((((({......)))}...))))))}((((.....(((((.....)))))....))))...})))..(((.(((.(((((..,.((((.(((((...(((((((.......)))))),...{{{........))}.(((((((...............({((((((.....)))))..))).{{{....))).....(((({...}))))...)))))))....................................(((((...)))))..((((.....)))).((((..........))))...))))).)))).,,.})))).))).))).}))))}}),.))))))...))).))),))..,,)))))))),}.}))}..}}}},.((((........)))),}},)))),))}},)))}}}.........((.....))......

Transcripts

ID Sequence Length GC content
NM_000300.4 NCBI
AGUGUCAGCCCGAAGGCUGAAGGAAAAAGAGCAACAGAUCCAGGGAGCA… 991 nt 0.5267
NM_001161727.2 NCBI
AGUGUCAGCCCGAAGGCUGAAGGAAAAAGAGCAACAGAUCCAGGGAGCA… 960 nt 0.5229
NM_001161728.2 NCBI
AGUGUCAGCCCGAAGGCUGAAGGAAAAAGAGCAACAGAUCCAGGGAGCA… 880 nt 0.5216
NM_001161729.1 NCBI
AGGGAGCAGCUAUUUAAGGGGAGCAGGAGUGCAGAACAAACAAGACGGC… 940 nt 0.5117
NM_001395463.1 NCBI
AAGACGGCCUGGGGAUACAACUCUGGAGUCCUCUGAGAGAGCCACCAAG… 846 nt 0.5225
Summary

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Forensic Context

A study in human and rat skin demonstrated that ultraviolet-B (UVB) irradiation significantly upregulates the PLA2G2A transcript, with fold changes of 11.6 in human and 13.8 in rat skin at the peak of hyperalgesia [Dawes et al. DOI:10.1371/journal.pone.0093338].