Basic Information

Symbol
PLAAT4
RNA class
mRNA
Alias
Phospholipase A And Acyltransferase 4 TIG3 RIG1 HRASLS4 PLAAT-4 RARRES3 Retinoic Acid Receptor Responder (Tazarotene Induced) 3 Retinoic Acid Receptor Responder Protein 3 Retinoic Acid Receptor Responder 3 Retinoid-Inducible Gene 1 Protein Tazarotene-Induced Gene 3 Protein RAR-Responsive Protein TIG3 HRAS-Like Suppressor 4 HRSL4 Phospholipase A/Acyltransferase‐4 Phospholipase A/Acyltransferase-4 Retinoic Acid-Inducible Gene 1 Retinoid-Inducible Gene 1 EC 3.1.1.32 EC 2.3.1.- EC 3.1.1.4 PLA1/2-3
Location (GRCh38)
11:63529451-63548808
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004585.5
Sequence length
758.0 nt
GC content
0.5303

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-259.50 kcal/mol
Thermodynamic ensemble
Free energy: -273.82 kcal/mol
Frequency: 0.0000
Diversity: 184.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((......)))))........(((((((((........)))))))))((((.(((.((((...))))......(((((.......(((((.((.....))..)))))((((.((((...))).).))))((((....))))((((((.........)))))))))))))).)))).........((((((((((((((((.(((...((((....))))..))).))..))))......(((((((((((..(((((.((((.((((((((((((.((((((((.((.(.((((.((((.((.((((((((((...(((((((((.(((...))).)))))))..))...)))))))).....(((((((((((((.(((....)))..)))))....))))))))..(((.(((...((((((.......))))))..))).))).....)))).)))).)))).).))))))).)))...((((..((((((((((....(((...)))...))))))))))....)))).....)))))))))((((.((((..........)))).))))...(((((((((((((....(.((((......)))))....))))))).))).)))...))).)))).))))))))))))))))..((((((((..((((((((....((..(((......)))..)).......))))).)))..)))))))).......)))))...)))))....
Thermodynamic Ensemble Prediction
...(((((......)))))........(((((((((........))))))))),,....((((((((..,,,,,.,...(((({,{..{{{((,(,.((.,,,,||.....||((((.((({...})).|.})))((((....})))((((((,,....,..))))))}|||,|}}..})}}})}.,.})))),,}})))}..,}})})},..,,,,{.{(((((..{(((.(((((((.{...((((.,{{,(((({,(.(((((.(((((((((((.((((.(((,(..(.((((((((({(.....)}.))},(((.((((((((((((((.{((.(((((((((..(.((..{{|{{.{(({...,,)}),..}},...)).)..)))}})))))))}.)))))}(((((((.(((..(((.((((...(((,.(((....))),.)))....))))..)))..))).)).)))))))))).))))))..,,,.((((((((((((.,.(((((........))))).,.)),......}))))))))).},.{{.||{(({......))))...,..,}}))))),}.,).))).)))).})}.))))))))))))),})))))}.,)))).))))).))).))))))))))}||,,,...((((((((..((((((((....((..(((......)))..)).......)))))},))..)))))))).......)))))))),,.......

Transcripts

ID Sequence Length GC content
NM_004585.5 NCBI
CCUUCAGCAUAAAAGCUGAUCCACAAACAAGAGGAGCACCAGACCUCCU… 758 nt 0.5303
Summary

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human traumatic brain injury (TBI) patients demonstrated that the PLAAT4 was identified as one of the four most significantly down-regulated mRNAs in brain contusion tissue compared to adjacent control tissue [Yang et al. DOI:10.4103/1673-5374.247467].