Basic Information

Symbol
PLAUR
RNA class
mRNA
Alias
Plasminogen Activator, Urokinase Receptor UPAR Urokinase Plasminogen Activator Surface Receptor URKR CD87 Urokinase-Type Plasminogen Activator (UPA) Receptor Monocyte Activation Antigen Mo3 U-PAR U-Plasminogen Activator Receptor Form 2 CD87 Antigen MO3
Location (GRCh38)
19:43646095-43670547
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from CNS diseases Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002659.4
Sequence length
1368.0 nt
GC content
0.5592

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-474.80 kcal/mol
Thermodynamic ensemble
Free energy: -500.78 kcal/mol
Frequency: 0.0000
Diversity: 343.33
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.((.((.((.(((((((((((...(((......)))))))....))))).)).)))))).))((.((....)).))..)))).((((.((((((..(((((((.(((.(((((((((.(((((.(((...(((((((......)))).))).....)))((.((((..(.((.(((((((((((.(((((....((((((.((((((..(((.((..((((.(((..((((.((.....)).))))..)))............((((.((((((....))))...)))))).....((((((((((...))))))).)))..(((((((.((((.(.....).)))).))))))).)))).)).))).))))))))).)))....)))..))....))))))(((((((.....)))))))...)))))..)).)..)))).)))))))))))))))).))).))))...).))..))))))))))..(((((((...(((((((..((((...(((((((...))))).))(((((....)))))(((((..(((..(((((....))))).......)))..)))))..........))))..)))))))....((.(((((((.((.....(((((((.((((..((.(((..((..........))..))).))))))((.(((......))))).((((((...(((((...)).))))))))).(((((.((((((.(((((...((((((((((...((..((..(((((((((.((..((((...............((((........))))..(((((((.......((.((((((((....(((((......((((...))))...)))))...)))))))).))....(((.(((((....((((......))))(((....)))......))))).)))(((((((((((....)))..))))))))......)))))))..........))))..)).)))))))))..))((..(((((......((((.......(((((..((((....((((....(((((((.((((((((............)))))))).).))))))...))))......).).))..))))))))).)))))..))))...))))))).((((((((((((.........(((.((.((((....)))).)))))..........)))))..)))))))....)))))))))))))))))))((((....)))).)))))))....)).))))))).))...(((.(((((....))))).))).........((((.........))))))))))).
Thermodynamic Ensemble Prediction
.(((({(.((.((.((.((((((({(((,..(((......)))})))....))))).)).)))))}.|,((.((..,.)).))..)))).((((.((((((..((((((({(((,{((((((((.(((((.((,...(({((((......)))).)))....,|}}((,((((..(.((.(((((((({((.{,({,,,{|{{((((.{(((((..(((.{{..((((.({(,,((((.{{.....}}.}}})..}}},,......{{..{{||,{{|||||,,.|,||...|||}}|....,||||||||{,.,,))))))}}))},}|{{{{{{.|{{{.{..,,,),))}),))))))).}))).)).))).))))))}))|||,..,,||}..}}....}}}})}(((((((.....)))))))...,}))),,)),),.))}}.)))))))))))))))))))).)))}..,).))..))))))))))..(((((((...(((((((..((((..{({(((((...))))).))(((((....)))))(((((..(((,{(((((....)))))....,}.)))..)))))..........))))..)))))))....((.(((((((.({.....(((((((.((((...{.(((..((..,.....,.))..))).,})))){,{(((......))))).((((({..,(((((...)).))))))))).{((((.((((((.(((((..,(({(((((((...({..{{..(((((((((.((.,(({{.....,...,}....,,{,.......,||||..(((((((.{,....||,((((((((....(((((......((((...}))}...)))))...)))))))).},.,,{{((.(((({....{{((,.,...})))|||,..,|||....},))))).)))|,|((((((,,...,))),.})},}}))......))))))),}}},.....})))..)).)))))))))..))((..(((((.,,.,.{{((.......(((((..{{......{(((....(((((((.((((((((............)))))))).)}))))))...}})}...,,,),).)}..)))))}})).)))))..))}}.,.))))))).{{((((((((((.........(((.((.((((....)))).)))))..........)))))).)))))))....))))))))))))))))))}((((....)))).)))))))...,)}.))))))).)}.,,{{{.{((((....})))).}}}.........{{{{.,,......}))}))))))).

Transcripts

ID Sequence Length GC content
NM_001005376.3 NCBI
AGGAGAGAAGACGUGCAGGGACCCCGCGCACAGGAGCUGCCCUCGCGAC… 1257 nt 0.5465
NM_001005377.3 NCBI
AGGAGAGAAGACGUGCAGGGACCCCGCGCACAGGAGCUGCCCUCGCGAC… 1233 nt 0.5556
NM_001301037.2 NCBI
AGGAGAGAAGACGUGCAGGGACCCCGCGCACAGGAGCUGCCCUCGCGAC… 1221 nt 0.5594
NM_002659.4 NCBI
AGGAGAGAAGACGUGCAGGGACCCCGCGCACAGGAGCUGCCCUCGCGAC… 1368 nt 0.5592
Summary

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that the PLAUR gene, identified via RNA sequencing, was significantly upregulated at 1, 4, and 7 days after spinal cord injury [Li et al. DOI:10.4103/1673-5374.255994]. In a separate study in weanling swine, microarray analysis showed the PLAUR transcript was significantly increased in skin at 7 days postexposure to both sulfur mustard and thermal burn injury, identifying it as a potential therapeutic target for wound healing [Price et al. DOI:10.080/15569520903097754].