This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [provided by RefSeq, Jul 2008]
Forensic Context
A study in human postmortem-derived iPSC neurons demonstrated that the POPDC2 was dysregulated in both cocaine use disorder (CUD) postmortem brain tissue and in isogenic iPSC-derived neurons following cocaine exposure [Mendez et al. DOI:10.3389/Fpsyt.2023.1070556].