Basic Information
Symbol
PPIH
RNA class
mRNA
Alias
Peptidylprolyl Isomerase H
USA-CYP
CYPH
Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H
Peptidyl-Prolyl Cis-Trans Isomerase H
Rotamase H
SnuCyp-20
PPIase H
CYP-20
U-SnRNP-Associated Cyclophilin SunCyp-20
U-SnRNP-Associated Cyclophilin SnuCyp-20
USA-CyP SnuCyp-20
Cyclophilin H
EC 5.2.1.8
MGC5016
Peptidyl Prolyl Isomerase H (Cyclophilin H)
CYP20
CypH
Location (GRCh38)
1:42658185-42676758
Forensic tag(s)
-
MANE select
Transcript ID
NM_006347.4
Sequence length
754.0 nt
GC content
0.4735
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-225.00 kcal/mol
Thermodynamic ensemble
Free energy:
-242.16 kcal/mol
Frequency:
0.0000
Diversity:
163.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((....(((((((((((((((((((((.(((((((...........)))).)))))))))).)))((((((.(..((....((((((((....))))))))))..).))))))((((.((((((.....((((((((.(......)...))))))))..))))))..))))...((..((.(((((((((..((.((((...((..(((((((..((((((.(((((((.((....)).)))))))...))))))(((((.......)))))((((((((.....))))))))...(((((((((..(.(((((....(((((..((((((((((.((.(...(((((((..(((....((..(((((.((..........)).)))))..))((((..(((((((((((((((((.((..(((........)))..)).)))))))))....((((((.(((....))).))))))........((((....(((((((((...........(((....))).))))))).)))))))))).)))).))))...((((........))))))).)))))))............).)))))))..)))))))))).))))).).)))))))))....))))))).)))))).))..)))))))))..))..)))))).))))))))))((((((....((((...))))))))))...........((((.(((((.....))))).))))..
Thermodynamic Ensemble Prediction
(((....((((((((((((({(((((((.(((((((...........)))},}))))))))).})){(((((.(,.,{....((((((((....))))))))}),.}.))))),((((.((((((.....((((((((..,........,))))))))..))))))..))))...{(..((.(((((((((..((.((((...,,..(((((((..{(((((.(((((((.{,....}}.)))))))...)))))){{{{{.......}))}}{(((((((.....)))))))}...(((((((((..{.(((((....,((((..{(((((((((.((.{,{{(((((((((((((({{((,,(({((,({,,,.......,),))))}|.}}||,,.,{({({((({{{,{|,|{,,,..|||..,}}}}})))}.}}})}}})))))....((((((.(((....))).)))))).......,({((....(((((((((...........{((....))).))))))).))})))})}},}}|||||||{.{((((........))))).},)}}}})),,}|........),))))))},,}))))))))}.))))).}.)))))))))....))))))).}})))).))..)))))))))..))..)})))).)))))))))){(((({....,,,,...}},,})))}}.,,,,....,,|(((.((((({...,))))).))),..
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GACUUCUGCUUCCGGGUCGGAGCCAUGGCGGUGGCAAAUUCAAGUCCUG… | 873 nt | 0.4800 | |
| GACUUCUGCUUCCGGGUCGGAGCCAUGGCGGUGGCAAAUUCAAGUCCUG… | 754 nt | 0.4735 |
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Forensic Context
No relevant information is available at the moment.