Basic Information

Symbol
PPP1R14A
RNA class
mRNA
Alias
Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A CPI-17 PPP1INL Protein Kinase C-Potentiated Inhibitor Protein Of 17 KDa 17 KDa PKC-Potentiated Inhibitory Protein Of PP1 Protein Phosphatase 1 Regulatory Subunit 14A PKC-Potentiated Inhibitory Protein Of PP1 17-KDa Protein CPI17 Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A 17-KDa PKC-Potentiated Inhibitory Protein Of PP1
Location (GRCh38)
19:38251237-38256557
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_033256.3
Sequence length
560.0 nt
GC content
0.6411

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-234.50 kcal/mol
Thermodynamic ensemble
Free energy: -244.28 kcal/mol
Frequency: 0.0000
Diversity: 177.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......(((((((((.((((....))))..((((((((..(((((((.(((.((((......)))).)))..)))).)))..))))))))((((....)))).((.(((.((((.((((((((((((...(..((.((((.((((.((((((....))))(.(((..((((((....))))))...))).)......))...)))).)))).))..)...))))).((.((((((........)))))))).(((..((((((.........))))))..)))(((((((((((((.(((.((((((......((((....)))).........(((...(((((.((((.(((......((((((........))))))))).)))).)))))...)))(((....)))......((((.(((...((.((..((....))..))))..)))..)))))))).)).))).........)))))).)))))))...)))))))))))))).))(((((((........))))))).......)))))))))........
Thermodynamic Ensemble Prediction
,,...{{(((((((((,(((({{,,||||.,(((({({(,{(((({{(.(((,((({.,,,,,||||,}}}..}|||,|||||||}}}}}}{(((|.{.}}},.|{||||.{{|||{|||||||||||...|,,||,||||.{|||.{{((({....})})||||,,,||||||..}.)),)))}}.|||.|,.....,,.},}))),|||},||,.|,.,|}}},.((.((((((........)))))))).{{{..((((((.{.....}.))))))..}}}(((((((((((((.{,{...{{((,...,}|,||,.,|},}|.,(((..((((({..{{{,..,|||,,,,.....,((.(((((((((..,(((.....((({....)))).....))).,..))))))..})).)}))))))}},((((({(...(((({{,...})...))))..)).))))),.....,,..)))))).)))))))...)))))))))})))).))||||||||}}},}}..,,||||,......,}}}}}}))..,.....

Transcripts

ID Sequence Length GC content
NM_001243947.2 NCBI
GCACAGCGCGGGGCCAGGCUGGGUCCAGCAGCGCGAUGGCAGCUCAGCG… 479 nt 0.6701
NM_033256.3 NCBI
GCACAGCGCGGGGCCAGGCUGGGUCCAGCAGCGCGAUGGCAGCUCAGCG… 560 nt 0.6411
Summary

The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

Forensic Context

A study in humans identified PPP1R14A as a specific gene marker defining the APOC1+/PPP1R14A+ fibroblast subcluster (FB2) within the corpus cavernosum, with its expression validated through single-cell RNA sequencing and spatial localization analysis [Zhao et al. DOI:10.1038/s41467-022-31950-9]. A study in mice demonstrated that the PPP1R14A was commonly up-regulated more than 2-fold in liver tissue following in vivo irradiation of Kupffer and endothelial cells with α-particles, as validated by real-time PCR [Roudkenar et al. DOI:10.1269/jrr.07078].