Basic Information

Symbol
PRAC1
RNA class
mRNA
Alias
PRAC1 Small Nuclear Protein C17orf92 PRAC Prostate Cancer Susceptibility Candidate Protein 1 Prostate, Rectum And Colon Expressed Gene Protein Prostate Cancer Susceptibility Candidate 1 Small Nuclear Protein PRAC1 Prostate Cancer Susceptibility Candidate Chromosome 17 Open Reading Frame 92 Prostate, Rectum And Colon Small Nuclear Protein PRAC
Location (GRCh38)
17:48721719-48723082
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mixture deconvolution Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032391.3
Sequence length
382.0 nt
GC content
0.4869

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-114.00 kcal/mol
Thermodynamic ensemble
Free energy: -121.21 kcal/mol
Frequency: 0.0000
Diversity: 78.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((.((((((.....(((((.(.....).))))).))))))((((..........))))...(((((((((......)))))))))(((...(((((((.....((((.(((((.....(((......))).....)))))))))....))))))).)))..........((.(((((((.((((((........)))))))).)).))).))..((((..((((......))))....))))((((((.(((....(((((((((((.....(((((((.(......).))))).))...))))))))))).))).))))))...((((..((((...)))))))).........................))))).
Thermodynamic Ensemble Prediction
..(((((,((((((.....(((((.{.....}.))))).))))))|(((,{,....}},)}}}...(((((((((......))))))))){((...(((((((.....{(((.{((((,....(((......,,)}}...))))))})}....))))))).}}},,,.......{{.{((((((.((((((........)))))))).}}.))).)}..((((..((((......))))....))))((((((.(((....(((((((((((.....(((((((.(,.....),))))).)).,.))))))))))).))).))))))...||||,,||||,,,)})},,.,,,......,,,,.............))))).

Transcripts

ID Sequence Length GC content
NM_032391.3 NCBI
CCUUCCUCUCCUAGCCUAAGGCGUGCAAACAGAGCGCCACUGGGAGGCU… 382 nt 0.4869
Summary

This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans established a multiplex system using coding single nucleotide polymorphisms (cSNPs) within semen-specific mRNA markers to deconvolute the semen donor in mixed body fluid stains [Liu et al. DOI:10.1016/j.fsigen.2021.102483]. The system incorporated the semen-specific mRNA marker PRAC1, which contains the cSNP rs1054072, and demonstrated high sensitivity and specificity, successfully typing the semen contributor in laboratory-generated mixtures with other body fluids at ratios as low as 1:10 for semen-blood and up to 1:200 for semen-menstrual blood, with genotyping results from cDNA being concordant with genomic DNA.