Basic Information
Symbol
PRB2
RNA class
mRNA
Alias
Proline Rich Protein BstNI Subfamily 2
PRPPRB1
CP7
Ps
Basic Salivary Proline-Rich Protein 2
Con1 Glycoprotein
Proline-Rich Protein BstNI, Subfamily-2 (Parotid Size Variant)
Salivary Proline-Rich Protein 2
Basic Proline-Rich Peptide P-E
Salivary Proline-Rich Protein
IB-9
Location (GRCh38)
12:11391540-11501041
Forensic tag(s)
Tissue/body fluid identification
MANE select
Transcript ID
NM_006248.4
Sequence length
1431.0 nt
GC content
0.5772
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-380.90 kcal/mol
Thermodynamic ensemble
Free energy:
-409.15 kcal/mol
Frequency:
0.0000
Diversity:
471.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((((((.(((..(((...((.(((((..(((((((...((((.(((((((.(((((((((.((((.((((((...))))))........(((.....)))....(((......)))...(((......)))...(((....)))((..((......))..))............(((((.........(((.(((.........(((((...........(((((.....)))))..))))).........))).))).........)))))..........(((((......((((..((((......(((((.((....))....((((....(((....)).)....))))....((((.........(((.(((........((((((...........(((((.....)))))..))))))........))).))).........))))...........)))))......))))..))))......))))).((....))....(((((..........((.(((.....)))))(((.(((..((((((((((.((....((....))....)).......((.(((.....)))))..(((((......((((...((....))...))))............(((((......((((..((((......(((((.((....))....(((((..........((.(((.....)))))...(((.......((((...((....))...)))).......)))..((.(((.....)))))..)))))......((((...((....))...))))............)))))......))))..))))......))))).((....))....)))))..........))))).))...)))..))).)))......((((...((....))...)))).............(((((.....)))))..)))))....((((((...((....((....)).......))...)))))).......(((..((((.....))))..)))...))))))))).))))..((....)).)))))))))))....))).....))))....)))))..)).....))).)))))))))..((((((............((((((.....((((((((((((............(((...))).))))))))))))........)))))).....((((((.....)))))).).)))))..(((((..((((((.(((((((.....((((((...(((((...........)))))....)))))))))(((.((....)).)))...))..)).))))))....)))))...............)))))..........................
Thermodynamic Ensemble Prediction
.(((.,{,((((((.(((.{({(...((,((((({..{{,||{,,.{{{||{{((({{{({(((((((.((((.((((((...))))))..,,.....,|,,..,}}}}}.||{,,|......,,,,|}|..,.}}}||,..||{....)))|},},}},....|((((,......,,,...(((((......{{{(,,.(({.........(({{{...........(((((.....)))))..|||||....,{{{{|...||,...,,....))}},....,....,|||||......,(({..{(({.....,}}}||,||....|}....||{|,...,{,...,(({{{...,||,....|,,...,.}}||||...||,...,,...,|||{{...........(((((.....)))))..||||||...,,{{{|...||,...,,....)),},....,....,|||||......,(({..{|||.....,)))},,||....||....|||||....,,....((,(({.....}}},|{{..,,,}.|.||||||...||....}}....||,,,..........((.(((.....)))))..|||||....{{{{{{...||,...{{....)),,....,,....,}||||......,{{|..{|||.....,)))},,||....||....||||,.....,,,..((.(((.....)))))...|||.......||||...||....}}...,||},,.....,....((.(((.....)))))..|||||....{{{{{|...||....{{....)),,,...,,....,))}||......,{{|..{|||.....,))),,,|}....,,....||}}}..,,,,....|||||.||...|||.,{{...,,},)..,||||.,.||,...}}....||||,...........(((((.....)))))..|||||....{{{{{|...||,...{{....)),,....,,,...,}||||......,{{|..{|||.....,))),,}}}....,,...,||,|,.{{{((...{(({((|.{,..{{{{....{{{{,...{,{{{....||,..,||....))},..,,},.....|,,||,......},,...((((((.....((((((((((((....,,...|..{{|...))}.))))))))))))..,.....)))))).....}|||)))}...))))),.}.}))),..|,}||}|...|||,,.}}}}}}{{.|{{{{...,...,,.}}}}}.})..{{{.{{.{((((.{.(((((.......{((({|,.....({(......))).....))))))....)))))..)))))}}.,,,..............,}}}))..
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AGCACAGAGUUGGGAGUGACUCCAGAGCCUCCUGCAAGAUGCUGUUGAU… | 1431 nt | 0.5772 |
Summary
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, May 2023]
Forensic Context
A study in human samples demonstrated that the PRB2 was identified as a reliable protein for saliva identification, being detected in 48 out of 50 saliva samples with an average sequence coverage of 46.64% [Brown et al. DOI:10.1021/acs.jproteome.5c00711].