Basic Information

Symbol
PRB3
RNA class
mRNA
Alias
Proline Rich Protein BstNI Subfamily 3 PRG Basic Salivary Proline-Rich Protein 3 Parotid Salivary Glycoprotein G1 Proline-Rich Protein G1 BstNI Type Basic Salivary Proline-Rich Protein 3 G1 Parotid Salivary Glycoprotein G1
Location (GRCh38)
12:11265914-11269707
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001394862.1
Sequence length
1227.0 nt
GC content
0.5860

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-334.60 kcal/mol
Thermodynamic ensemble
Free energy: -358.58 kcal/mol
Frequency: 0.0000
Diversity: 416.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((((((..((((((..(((((.(...((((...))))...).)))))..)))(((((.(((.((((((((((((((......)))))).......(((((.....(((.((...)).))).....))))).((....))....((((((........((((((......((......))......))))))...((...(((....((((...((((....)).))......))))...)))...))...)))))))))...))))).))).))))).......(((((......(((((.(((((..((.(((.((..(((....((....))....)))..)).))).)).............((((..((.(((.((..(((....((....))....)))..)).))).))......((((...(((..((((.......))))...)))....))))..(((((...((((((......((((...(((..((((.......))))...)))....))))...........(((((......(((((..(((((...((((..((((((....((....))....)))......((((((............(((((.........(((.(((.........(((((....((....)).(((......)))...))))).........))).))).........)))))...........((((.......))))..(((((.........(((.(((.........(((((...((.((.(((.((..(((........)))..))..))).))...)).......(((((....))))).....((((.......))))..))))).........))).))).........)))))............((((.....))))...........)))))).))))))).....)))))....(((.(.(((((.........((((...))))..))))).).))).........)))))..))))).))))))...)))))..)))).....))))).....)))))..)))))((.........))(((((((.((((...((((((.(((...........)))...)).))))....)).)).))))))).((((((((........)))))))).....................)))..))).))))).
Thermodynamic Ensemble Prediction
....((((((((.{(({({(..(((((.{...((({...,))}...).})))),,)}}(((((.(((.(((((,(((((({{.,,,,,)}}}}},......{{{{{.,,,..(({.,....},),|||...}}}}}.{{....}}....((((((.{,,,...{(((((......{{......}}......))))))...||...,||....(((({.,{,({....)).||...,,.}}}}...|||...,..},)))))).||...})),}.,||,||,}|,,,....||,((....,.{{{{,..|||,.,|,.|||.||..|||....{{....)),|..|||{,,,.,)).||......,|||...|||||,,,.,,|.||,,|||...,||....||||,.|||{,....}}.||......||||...|||||{{{|,.,.,},}}}}...}||....))|}}.||{{,....||,||......{{||...|||{|{{{{,.,..,,}}|}...,||....))}},.||{{{...,||{||......{{{{,..((({{{{{(.......})))...,}}....))}},.,{{{{...,||,((......,{{{...|||{{,,..,,,.,|,,|||,..,,,....|||||.,{{{,...,||.{{......,|||...|||||.....,,..||||||,...,,....|||||..........}((((.......}}}}..|||||.........{{{.|||.........|||||..,,{,...,||.((..,,,..,,,...|||{{.,..,,,..|{{.||,......(((((....))))).....((((.......))))..)))}}.....,,..))).))).........)))))..........{.{(((.....))))}...,,...{|||||...||,.||{,....)),))..,,,....,|||||,........(({{...))}}..,,,,,.}||}}...,,.,,.)))))..,,,,,.))))))...)))))..,........}}))).....))))).,))))),,.,.......}|(((({({.{{{{...{{{{{{.,,..{{.....|,,}}|...}).})))....)).)).}))))),.((((((((........)))))))).....................))),.)))}}}))).

Transcripts

ID Sequence Length GC content
NM_001394862.1 NCBI
AGCACAGAGUUGGGAGUGACUCCAGAGCCUCCAGCAAGAUGCUACUGAU… 1227 nt 0.5860
NM_006249.5 NCBI
AGCACAGAGUUGGGAGUGACUCCAGAGCCUCCAGCAAGAUGCUACUGAU… 1101 nt 0.5822
Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

Forensic Context

A study in humans demonstrated that the PRB3 is a saliva-specific mRNA containing a coding region SNP (cSNP) used for directly associating body fluids with donors in forensic mixtures [Ingold et al. DOI:10.1007/s00414-020-02252-w]. Subsequent research developed a target RNA sequencing panel including the PRB3, where it showed expression almost restricted to saliva and contributed to a cumulative discriminatory power of 0.987325116 for saliva identification, though the SNP rs1896551 on this transcript was noted to be affected by heterozygous imbalance [Yu et al. DOI:10.1016/j.fsigen.2025.103416].