Basic Information

Symbol
PRDX1
RNA class
mRNA
Alias
Peroxiredoxin 1 NKEFA PAGA Thioredoxin-Dependent Peroxide Reductase 2 Natural Killer Cell-Enhancing Factor A Proliferation-Associated Gene Protein Thioredoxin-Dependent Peroxiredoxin 1 Thioredoxin Peroxidase 2 Peroxiredoxin-1 NKEF-A TDPX2 PAGB PAG Epididymis Secretory Sperm Binding Protein Natural Killer-Enhancing Factor A Proliferation-Associated Gene A EC 1.11.1.24 EC 1.11.1.15 EC 1.11.1 MSP23 PRX1 PRXI
Location (GRCh38)
1:45510914-45542816
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_181697.3
Sequence length
945.0 nt
GC content
0.4624

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-291.60 kcal/mol
Thermodynamic ensemble
Free energy: -309.91 kcal/mol
Frequency: 0.0000
Diversity: 264.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.((....((..(.(((.(((.((((((.(((.((((....)))))))..))))))..((((.((....((((...((((.......)))).))))....)).))))...)))))).).))...)).))))).((((((((((((((......)))))((((((((((((....(((...((((((.((..(((..((((...(((((....(((.(((.((.((((.(((((.....(((((((..(.(.(((((((((((((..((((....((.((((((.(((((....((((....)))).............((((((((....(.(((........))).)......)))))))).......((((((........)))))).)))))))))))..))....)))).))))))(((((..((((.(.....).))))..)))))((((((((....))))))))..)))))))).)..)))))))..))))).)))).))..))))))...))))).)))).....((((((((...(((((((((...(.(((((.....(((((((((((.....(((...((((.....(((..((((...)))).))).....))))....))).....))))))))))).(((((((.(.(((((((......)))))))((((((((.....)))))).))..........).)))))))..........................(((((.((((((((....))))).))).)))))......((((((.(((((((.(((((.((((((......)))))).))))).))))))).)))))).))))).)...)))).))))))))))))).......)))..)).))))))...)))...))))))))))))..........)))))))))..
Thermodynamic Ensemble Prediction
...((((((((..({{,{,,,.||}|{(,{((((((.{((,,...,)),))))))))}((((((..((((((((.,{{...,,,,......(((({...}))))...........{||,.,{(((....{{{.,.}))}}}}}}..})))))))..)))))).((((((((((((....(((...((((((.((..(((..((.,.{{...(((...((.((((((((((,((((((((....}}||}||..(((((,{((,{{{.,,||.,||..}}|||,{{{,.}}}}||{|,,,{||||..,|{{{{{{{{|...{{,,(,((((({....{.(((,.......|||.|{{{{{{||,||,||{{{....((((((........)))))).{,,,,,,}}}|,.,}....}}}(((((((((((((......))).((((((((((.((((...,(((({....))))){(((...((....((((....))))....))...))))...)))).),...})))))))))))))))))}.|}}||||..|}}}}||||.||......,.||||,,,||||,},}}|||}}.((((...,.(((..(({,..,))}}.))).,...))))...|||},,,..,,,))))))},.}}}}})))))|((((({|,...,)))))))|,((((((.....))))))..{((........}))}},}},..........,}},,.}},,.,,,,,(((((.{(({((((....))))).))).))))).(((..((((((.(((((((.{((((.((((((......)))))).))))}.))))))).))))))..))).}.}})}))))).))....)))..})..)).)))..)).))))))...)))...)))))))))))).,,......,..)))).)))}

Transcripts

ID Sequence Length GC content
NM_001202431.2 NCBI
GUGCUUGUAGUCCCAGACACUCCGGAGGUGAGGCGGGAGAAUCGCUUGA… 1002 nt 0.4770
NM_002574.4 NCBI
GCGUCUUGUUCUUGCCUGGUGUCGGUGGUUAGUUUCUGCGACUUGUGUU… 1165 nt 0.5107
NM_181696.3 NCBI
GCGUCUUGUUCUUGCCUGGUGUCGGUGGUUAGUUUCUGCGACUUGUGUU… 1139 nt 0.5083
NM_181697.3 NCBI
GCGUCUUGUUCUUGCCUGGUGUCGGUGGUUAGUUUCUGCGACUUGUGUU… 945 nt 0.4624
Summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Forensic Context

A study in humans and mice demonstrated that peroxiredoxin-1 (PRDX1) was identified as a differentially expressed protein present in serum exosomes from septic patients but not in healthy individuals [Li et al. DOI:10.1016/j.jare.2021.11.005]. A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated transcription factors in cortical glial cells, with Zbtb16, Hif3a, Foxo1, and Klf9 being notably altered across astrocytes, microglia, and oligodendrocytes [Oladapo et al. DOI:10.3390/Ijms26020649].