Basic Information

Symbol
PRDX3
RNA class
mRNA
Alias
Peroxiredoxin 3 AOP-1 Antioxidant Protein 1 SP-22 MER5 AOP1 Thioredoxin-Dependent Peroxide Reductase, Mitochondrial Thioredoxin-Dependent Peroxiredoxin 3 Protein MER5 Homolog Peroxiredoxin III Prx-III HBC189 Epididymis Secretory Sperm Binding Protein Peroxiredoxin-3 EC 1.11.1.24 EC 1.11.1.15 PRO1748 SCAR32 PPPCD
Location (GRCh38)
10:119167699-119178865
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006793.5
Sequence length
1553.0 nt
GC content
0.4018

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-405.80 kcal/mol
Thermodynamic ensemble
Free energy: -439.31 kcal/mol
Frequency: 0.0000
Diversity: 500.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.(((((((....(((((((((((((((((((((((..(((((((((.(((((....)))))..(((.....)))..))))))))).((((.((((((((((((...))...)))))).)))).))))...(((((((.......................)))))))..........((((((((((((((.......(((..(((((.....))))))))(((((......)))))......((((((((.((((.(((....)))))...)))))))))).....))))))....))))))))........((((...))))..(((....))))))))))))....((((((((...))))))))........(((((((((........)))))))))...))))))..(((((....)))))...))))))))((((((((.....(((((........)))))))))))))...(((((....((.(((((((.(((((.((((.(((((.....(((......)))....)))))....))))..))))).)))...))))))...)))))...((((((....)).))))....))))))).)))))).......(((...)))....(((.(((((((((...((.(.(((((((((((((((.((..((((((.((((((((.(..((((((..((((..((((((...((..((......)).....))..)))))).))))......((.((((((...))))))..)).))))))..))))))))).)))))).((((((......))))))(((((...((((((..............))))))..)))))..(((((((.((((((.........((((((((....))))))))........(((((((((..........(((((((.(.((.......((.(((..((((((((((.((((...))))))))))))))))).))......)))))))))).....)))))))))..)))))))))))))(((((((.....(((...(((.((....)).)))....)))....))))))).........((((((((......)))).)))).......((((((.(((.((((...))))..))).)))))).)).))))))))))..))))).).))..))))))))).)))..((((((..((((((....((((((....((((((.(((((..((((((((((.(((((((((.((....((((((............((((..((.(((((((((...........((((((...((((..........)))).))))))))))))))).))..))))))))))..((((((..((((((.(.......)))))))..).)))))))..)))))))))..))))))))))......))))).)))))).....))))))))))))..)))))).((((((((...(((((.....))))).......)))))))).....
Thermodynamic Ensemble Prediction
,(((({{.{({((,(((((,,((({((((({{((((((((((,.(((((((((.(((((....)))))..,.{|||.,}}},,))))))))}.{(({.(((((((((({{...})...)))))).)))).}))}...(((((((.{{{{..........,|,,....)))))))..........{(((((((((((((.,,,...(((..(((((.....))))))))(((((......))))).,,,,,((({{{{{.((((,({(....|}|||...}}})}}}))),,,..)))))}....}))))))}.....,,,{,,,..,))),..{{{....}}}}))))))))|,,.(((((((({,.,,,,,,))}}}.,}},|{{{(((({....,.,,|||||}}}}}))))})))}}||||{,,,}}}}},.,,{((({{{{{,.{{(,,.....(((((........)))))||||}|}||||{{{{{....({.((((((({(((((.{{((.(((((....,(((......))).}..)))))....))))..))))}.)})}.}))))}}...}}}},...{{{||||..,))|)))},,,,||.,},,,)}}}}...}},}}}}},}))})}}}||||({(({.,....,,}}))),|{({(((((({{{,.{,..((((((.((((((((.(..((((((..((({..((((((...{(,,{,,,....)).....}}..)))))).))))......((.((((({...}))))}..}}.))))))..})))))))).)))))).((((((......)))))),,,|...}||||,,..,}}}}}}}}}}.,,|}}}||}))}}.,((((((,,((((({.........((((((((....))))))))..........{{{,((({{{{(((,..(((((({,(.((...,...((.(({..((((((((((.((((...))))))))))))))})).)).},,..))))))))))..,.)))))))))..,}))))))))))))|((((((.....(((...(((.((....)).)))....)))....))))))}.........((((((((......)))).))))....,,.{((({{.(((.((({...}))}..}}}.}}}))},,||||||{(((((((.,{{,,..((,...,}.)))},....})))))),}||..,,,}},}|}}||,}}}|{(({..,..((({(((({{{{{{..,{{{{{,,{{({{{.{,|{{|.|{||,||{{{{{{{{{{,|||,|||.}},..,}}{{{{{.,,.}}|}}.,,.{{{{{((,,,.{(({{..{{{.,,,))}.,.})}}}.}}|,.{,{{{,((((((..((((((.{.......,))))))..).))))).})}}.}}|,|||,,,|||.,,,,}..,,}})))))))})}}},}}||||},|,,.,,)}))})}})))}}})}))))))}})}}.....)))}|,,,,....,,,,,,......

Transcripts

ID Sequence Length GC content
NM_001302272.2 NCBI
GUGGCGCCCGAGUGCACUGAAGAUGGCGGCUGCUGUAGGACGGUUGCUC… 1387 nt 0.3872
NM_006793.5 NCBI
GUGGCGCCCGAGUGCACUGAAGAUGGCGGCUGCUGUAGGACGGUUGCUC… 1553 nt 0.4018
Summary

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Forensic Context

A study in mice demonstrated that the PRDX3 was upregulated in common in splenocytes at day 7 post-injury following both burn and trauma-hemorrhage, where it was categorized as a gene expression marker for chromosome segregation [Lederer et al. DOI:10.1152/physiolgenomics.00086.2007]. In human sepsis patients, proteomic and transcriptomic analyses identified the PRDX3 as a potential biomarker, with its mRNA expression pattern found to be consistent with its corresponding protein level, indicating it was lowly expressed in the sepsis group based on RNA sequencing data [Wang et al. DOI:10.2147/IDR.S380137].