Basic Information

Symbol
PRDX5
RNA class
mRNA
Alias
Peroxiredoxin 5 AOEB166 ACR1 PLP Peroxisomal Antioxidant Enzyme Liver Tissue 2D-Page Spot 71B Thioredoxin Peroxidase PMP20 Antioxidant Enzyme B166 TPx Type VI SBBI10 PMP20 PRDX6 PRXV B166 Thioredoxin-Dependent Peroxiredoxin 5 Peroxiredoxin-5, Mitochondrial Alu Co-Repressor 1 Peroxiredoxin V MGC142285 MGC117264 MGC142283 Prx-V Epididymis Secretory Protein Li 55 Thioredoxin Reductase Alu Corepressor 1 EC 1.11.1.24 EC 1.11.1.15 HEL-S-55
Location (GRCh38)
11:64318041-64321822
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012094.5
Sequence length
860.0 nt
GC content
0.6058

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-366.20 kcal/mol
Thermodynamic ensemble
Free energy: -380.37 kcal/mol
Frequency: 0.0000
Diversity: 322.71
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((((.((((((((.((((.((.((((((((((((.....)))).)))))).)).))..)))).)))))....((((((((.((((...(((..((.(((((..((((.((((((((((((((((((((((....((.(((((((...))))))))).)))))))....((....))...((......)).........)))))))))..)))))).))))...)))))))..)))))))..))))))))(((.....(.(((((.......))))).)..)))..((.((((((.((..((((((............))))))....)).)))))).)).....(((((((...(((((((.(((.((((......)))).)))..))))))).)))))))((((((((...(((.(((((.(((((((.....)))).((((((....(((((.((...(((((.((........((((((.....(((.(..(((((......)))))..).))))))))).((.((((((...)))))).))..((((((((((.((((((........)))......(((((((.....((((((((((..((((((((............))))).))).)))))..((((...(((..((((.((((.....((((...((....)))))))))))))).)))..)))))))))....))))))).....))).))))))))))))))))).....)).))))).))))))...))))))))))))))))).))))).)))))))....))))...(((((.(....((((((.......))))))....))))))
Thermodynamic Ensemble Prediction
.(((((((((((,,,{(((((,((((,((.((((((((((((.....)))).)))))).||.,}..)))|,|}|||..,{((((.({.((((((((((,,.((.((((((((.(..,.....}.}))).)))).))}}.))))))))))..|}.))))}|}||}}}.))))),||}}||||.||.||,||,|,|{|{{.,{,,,,({(((,{(({{{{|{{||||||.,{{||{||,...|||||||.|}.{|||||||{.....{,||||,...|}}})}||,}}}}})){{{||||,{{|{(({,((((((..,{...,}...)))))|{(((((((...{((,......(((((((((((.{(((.(((((..((((((((.|({{||.((((((|..,{{.{(((....)))).)})))))))..}|,|))...)))))))).})))),)))|(((((.(((((((({{.,{........{((({{.....{{|||..{{((({{{{{{||,,,..,,|,,,,,)),.}))|||||}}}.}))}},,}|{{({(((((((({{{.,{{,,,.....))}.,,.|||||{,{{{{,{{{{((,(((((..{(((((((..,.......,.))))),))).)))))..|}}|}},}||}}}}}}})))))},..,}})}..,}},..}},)))))))))))))))))),,,)))))).......))).))))))))).||||},.))))}|},.....,,.,,.}},)))))).,}}))))),((((((.....)))))))))))))....)))}...{((((.{....((((({.......))))))..,.})))),

Transcripts

ID Sequence Length GC content
NM_001358511.2 NCBI
CUUCCGCAGGGUGUCGCCGCUGUGCCGCUAGCGGUGCCCCGCCUGCUGC… 725 nt 0.6110
NM_001358516.2 NCBI
AGUCUGCGGCAGCGGCAGCAAGACGGUACAGUGAAGGAGAGUGGGCGUC… 695 nt 0.5799
NM_012094.5 NCBI
CUUCCGCAGGGUGUCGCCGCUGUGCCGCUAGCGGUGCCCCGCCUGCUGC… 860 nt 0.6058
NM_181651.3 NCBI
CUUCCGCAGGGUGUCGCCGCUGUGCCGCUAGCGGUGCCCCGCCUGCUGC… 728 nt 0.6058
NM_181652.3 NCBI
CUUCCGCAGGGUGUCGCCGCUGUGCCGCUAGCGGUGCCCCGCCUGCUGC… 593 nt 0.6121
Summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

Forensic Context

A study in rats demonstrated that the PRDX5 was significantly altered in expression in liver tissue on day 4 following a 20% total body surface area burn injury [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].