Proline Rich Protein HaeIII Subfamily 2
Pr
Acidic Salivary Proline-Rich Protein, HaeIII Type, 2
Salivary Acidic Proline-Rich Phosphoprotein 1/2
Parotid Proline-Rich Protein 1/2
Parotid Double-Band Protein
Parotid Acidic Protein
PRP-1/PRP-2
Protein C
Pr1/Pr2
Parotid Isoelectric Focusing Variant Protein
Parotid Proline-Rich Protein
PIF-S
Db-S
Pa
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
Forensic Context
A study in humans developed an RT-qPCR procedure for discriminating nasal secretion and saliva, where the PRH2 was evaluated as a candidate saliva marker [Akutsu et al. DOI:10.3390/diagnostics10080519].