Basic Information

Symbol
PRSS1
RNA class
mRNA
Alias
Serine Protease 1 TRY1 Cationic Trypsinogen Protease, Serine 1 Anionic Trypsin I Pretrypsinogen I Beta-Trypsin EC 3.4.21.4 TRYP1 TRP1 Nonfunctional Trypsin 1 Digestive Zymogen Anionic Trypsin-I TCR V Beta 4.1 Trypsinogen 1 Trypsinogen A Trypsin 1 Trypsin I Trypsin-1 EC 3.4.21 TRY4
Location (GRCh38)
7:142749468-142753072
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002769.5
Sequence length
809.0 nt
GC content
0.5365

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-268.60 kcal/mol
Thermodynamic ensemble
Free energy: -286.04 kcal/mol
Frequency: 0.0000
Diversity: 198.90
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((....((((((.(((((.((.((((((((((((..((((((((((.......))))(((((..((((..((....))..))))..)))))))))))..)))))).((((((((((((((..((((....))))......(((((((((....)))))))))(((.((.((..((((((((((.(((.(((((((....))))).........(((((((((.((((..((((((((..(((((.((.(((.(((.((((.((((((.((........)).)).....))))...)).)).)))......((((.....))))......))).)))))))......))))))))((((((..((.....))...)))))).........))))........(((((.((((.....(((((...)))))......))))..)))))..((((((.((((((((.(.......))))...)))))))))))))))))))).((((.((...))))))........)).))).))))).((((........)))).....))))))))).)))........)))).))).)))))))..)))))))))))))))))))....))).........(((((((((....))))))))).(((((((..(((((((...(((........((((((........)).)))).((((....))))..((((..........))))..)))...)))))))..).))))))..........(((.((..........)).)))...........
Thermodynamic Ensemble Prediction
.(((....((((((.(((({,((.((((((((({,,.,(((((((((({(({..{||{(((({({{((,((((({.,...,,|,,|{{||||||,||,.{{|,||||.((,,,,,,||,|||.,}|||,}}})))}}..,},(((((((((....))))))))).,.}))))).}}||.|}.}))}}}}}..}}}}|....)))))}}}},....(((((((((.((((.,((((((((....,,,.{,.{(({((,.((((..((.((.(...{{{...}..,,...}}),,,}.}))},})))....,..||||,....}}}},.,..{{||..}}))))......)))))))}((((((..((.....))...)))))).......,})),,........(((((.((((.....(((((...)))))......))))..)))))..((((((.((((((((.{.......})))},.,})))))))))))))))))).((((.((...)))))),.....,.,,,|((((({.,,,,{({,.{.,{{|||{,,,..,,,,))),)))),}}}))..,}))))))),)))}}}}..}))))))))))))))))))....))),...,,...(((((((((....))))))))).(((((((..(((((((...(((........((((((........)),}))}.,.,..{{{||||..,{{,........,,})))}})))...)))))))..))))))))..........{{{.{{.,........}},))}...,....,..

Transcripts

ID Sequence Length GC content
NM_002769.5 NCBI
ACACUCUACCACCAUGAAUCCACUCCUGAUCCUUACCUUUGUGGCAGCU… 809 nt 0.5365
Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human postmortem tissues from a cancer research autopsy program demonstrated that the RNA integrity number (RIN) of normal tissues declines with increasing postmortem interval (PMI) in a tissue-specific manner, while RNA quality in cancer tissues was highly variable and showed no correlation with PMI [Fan et al. DOI:10.18632/oncotarget.11836].