Basic Information

Symbol
PRSS2
RNA class
mRNA
Alias
Serine Protease 2 TRY2 Anionic Trypsinogen Protease, Serine 2 EC 3.4.21.4 Trypsin II Trypsin-2 TRYP2 Protease Serine 2 Preproprotein Protease, Serine, 2 (Trypsin 2) Trypsinogen 2 Trypsin 2 EC 3.4.21 TRY8
Location (GRCh38)
7:142760398-142774564
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002770.4
Sequence length
809.0 nt
GC content
0.5513

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-274.50 kcal/mol
Thermodynamic ensemble
Free energy: -288.17 kcal/mol
Frequency: 0.0000
Diversity: 206.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((....((((((.(((((.........(((((((...(((.(((((....))))).((((((..((((..((....))..))))..)))))).)))...)))))))..........((((..((((.(((((((.......((((((.(....).))))))((((((....(((.(((((((((((((.(.((((((..........((((.(((......))).))))((((((((...................((((.(((((...)))))....((((..........))))..))))........((((.(((.((........))..))).)))).....)))))))).)))))).).)))))...))))).))).))).........((((((((((((.......(((((....(((...)))....))))).))))))((((((((((((((((.(.......))))))...))).))..((((((..((......))....)))))).))))))......(((......)))..........(((........)))))))))......))))))..))))))).))))..)))).)))))))))))....)))..........((((((....((((......))))((((((.(((((((...(((......((((((((........)).))))))....(((((((..((......))..)).))))))))...))))))).)))))).((((.((.....................)).))))..))))))..
Thermodynamic Ensemble Prediction
.{{{....((((((.(((((.....,...(((((((...(((.(((((....))))).((((((..{(((..((....}}..))))..)))))).)))...))))))),,,.......((((..((((.(((((((......{((((((.(....).))))))|{{{{{....(((.(((((((((((((.(.((((({..........{(((.(((......))).))))((((((((.......,....,..|,,.((((.((((,...}))))....((((..........))))..))))........((((.(((.{{,,......}}..))).)))).....)))))))}.)))))).).)))))...))))).))).))).........({{{{{((((((..,(({{(,,{{....(((...}}}..},}))))})))))),{{{{{,||{{{((((|{....,,,}}}))},}.|||.|||,(({{((,.{{.,}.},)),},,))}|)),}}}}}}..}}}}{((.....,}||..,....,,,{{{........})})))))).,,.,.})))))},))))))).))))..)))).)))))))))))....}}|.,,,,,...}||||((.,,.{(({......}}|}((((((.(((((((...{{{......{{{{{(((.|,.....}}..|||||,,,.{{{||||,,||......}),.)}},)}|}}))...))))))).)))))).||||.,...{{{({,.{,..........)).))},,,)),,}}..

Transcripts

ID Sequence Length GC content
NM_001303414.2 NCBI
ACACUCUACCACCAUGAAUCUACUUCUGAUCCUUACCUUUGUUGCAGCU… 851 nt 0.5417
NM_002770.4 NCBI
ACACUCUACCACCAUGAAUCUACUUCUGAUCCUUACCUUUGUUGCAGCU… 809 nt 0.5513
Summary

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Forensic Context

A study in human whole blood from septic acute kidney injury patients identified the PRSS2 as a key hub gene within the protein-protein interaction network of the disease's regulatory ceRNA network [Ma et al. DOI:10.3389/fgene.2023.1209042].