Basic Information

Symbol
PRSS3
RNA class
mRNA
Alias
Serine Protease 3 TRY3 TRY4 Mesotrypsin PRSS4 Protease, Serine, 4 (Trypsin 4, Brain) Protease, Serine 3 Brain Trypsinogen Mesotrypsinogen Trypsin III EC 3.4.21.4 Trypsin IV Trypsin-3 Protease, Serine, 3 (Mesotrypsin) Pancreatic Trypsinogen III Serine Protease 4 Trypsinogen IV Trypsinogen 4 Trypsinogen 5 EC 3.4.21 MTG T9
Location (GRCh38)
9:33750679-33799231
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002771.4
Sequence length
808.0 nt
GC content
0.5557

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-287.00 kcal/mol
Thermodynamic ensemble
Free energy: -301.02 kcal/mol
Frequency: 0.0000
Diversity: 201.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((....((((((.((.((.((..(((((((((((((..(((((((((((((.(((((.(((((....((.((((((..(((..(((.((((..(((((((.(.(((((....))))).)...))))))))))).))))))((((.((.(....).)).))))...)))))).))...)).)))))))).))))))))).))))..((..(((.((((((((((....((((((((((((........(((.(((((((((..((.((((.........((((..........)))).................((((((.(.((.(((((((..((.(.(((...........)))).))..)))))...)))).).)))))).........)))).))...)))))))))..)))(((.(.((((((((((.(....).))))))...)))).).)))...)))))..)).)))))((........))))))))))))...)))..))....(((((........)))))....((((.((..((...(((((((......)))).)))...)).)).))))))))))))))......))).)))).))))))))....)))(.(((((..(((((((((....)))))))))((.(((((..((((((((((((......))))).(((.((((.......((((((((....)))))))).......)))).))).........)))))))..))))).))......))))).)......(((......)))...........
Thermodynamic Ensemble Prediction
.{{{....((((((.((.,.{{{..({(((((((((((,{(((((((((((((.(((((.((((,,{{.((.((((({..(((..(((.((((..(((((((,(.(((((....))))).}.,.))))))))))).))}})){({{.(({(,...}.)),))},.,.)))))).))..,)).)))})))).))))))))).}}})..,||,,{{,(({(((((({,,|.{(((({{(((({..{{{{{.(((.(((((((((..((.((((.........({((,.........)})),...............,((((((.{,((.(((((((..((.(.(((...........))),,))..)))))...))}),).)))))).........)))).))...)))))))))..|||(((,,.((((((((((.(....).)))))),..|)))..,||||,}||}|||.}}.}})))||,.,},..,}})))}||}}}}...}}}}}}..,},|((((........))))},,..{||||||..{,...({{((((......)))),))),,}}||},.})))))))))))))....,.))).)})).))))))))...,|||(.(((((..(((((((((....)))))))))((.(((((..((((((((((((......))))).(((.((((...,,..((((((((....)))))))),,.....)))).))).........)))))))..))))).))......))))).,.....,||,....,}})},...,,,....

Transcripts

ID Sequence Length GC content
NM_001197097.3 NCBI
ACUUGGCGAGCGGCGCGGGAUGCAGACGGCUGCGAGGCGCUGGGCACAG… 932 nt 0.5601
NM_001197098.1 NCBI
GGUUCCGACUCGCAUGGGACCUGCGGGGGAGGUUGCUGUCCCCUUUGAC… 803 nt 0.5554
NM_002771.4 NCBI
ACACUCUACCACCAUGAAUCCAUUCCUGAUCCUUGCCUUUGUGGGAGCU… 808 nt 0.5557
NM_007343.4 NCBI
ACUUGGCGAGCGGCGCGGGAUGCAGACGGCUGCGAGGCGCUGGGCACAG… 804 nt 0.5697
Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Forensic Context

A study in human acute and chronic skin wounds demonstrated that the PRSS3 is expressed in migrating keratinocytes (Bas-mig, Spi-mig) [Liu et al. DOI:10.1016/j.stem.2024.11.013].