Basic Information

Symbol
PRTN3
RNA class
mRNA
Alias
Proteinase 3 PR-3 AGP7 P29 Myeloblastin C-ANCA ACPA MBT Wegener Granulomatosis Autoantigen Serine Proteinase, Neutrophil Neutrophil Proteinase 4 Leukocyte Proteinase 3 Wegener Autoantigen C-ANCA Antigen NP-4 MBN PR3 Azurophil Granule Protein 7 EC 3.4.21.76 EC 3.4.21 CANCA NP4
Location (GRCh38)
19:840999-848175
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002777.4
Sequence length
987.0 nt
GC content
0.6646

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-413.90 kcal/mol
Thermodynamic ensemble
Free energy: -428.64 kcal/mol
Frequency: 0.0000
Diversity: 251.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(((....(((.....(((......)))..))).))).))))((((.((((((((((((((((.(.((.((((((((.((((((....(((((......)))))..)))))).........((((......))))(((((((....)))))))....))))))))..((((((((...((((.(((..........((((((.((.....(((((((((((((((.(((.....)))))).))..))))..)))))))).))))))...))).))))...)))))))).)).).))))))))....((((.((...((.((((((((..(((...(((((.(((((((............))))))).......((((((..((...))....)))))).....))))).(((((...((((.((...((((((((.....(((((....)))))((((...))))...((((((((((...(((((....)))))...)))))))))))))))))).))))))....((((..(.(((((((((((((((((((((.........((((................))))))))))))........)))))...)))))))))..))))))))).(((((.(((((..(((....((......))..)))..)))))))))).((((((.................((.((((((((.....((((((.((....)).))))))..((((.(((.(((((...((((....))))........)))))))).)))).((((((....))).))).))))....)))).))))))))....)))..)))))))).))...))))))....(((((.(...(((((((......)))))))))))))(((((.(((...)))....)))))..))))))))...)))).((((......))))..(((((....)))))......
Thermodynamic Ensemble Prediction
(((({,,..,,.(((,....(((......)))..||.{|||{||||,((({(,((((...(((((((,(((((((((((((.((((((....(((((......)))))..)))))).........((((......))))(((((((....)))))))....)))))))},)),...((((((((((..{({....,,.{{((...,.||}}..|{(((((((({(((((.(((.....)))))).))..)))}..}||||}||{|||}}}||,|...|})|||((((..((({{{(((.((........)).))))))))..)))),,,,,..,......{{.{.(((((((............))))))).).}}..((((.,.....)))).....}}}))))))))))}}},,}}}|.,})}.)}}})}|||||||,.}}}}|.||.,,{.(((((...))))))))}..((((((((((...(((((....)))))...))))))))))))))),,,.((((.(((((((....{.((((((.......((((((((.........((((.....,,.....,,..))))))))))))..,(({(((.(((.(((((.,....)))))))).))).}))|{((({.(((((......))))).))))}.{((((,.((((..,({((((((((((.({...,((((((((((((((......,(((((.((....)).)))))))))).)))))))))|({{..,||}}({{{{,{{.(((({,,,,.....|,||.((((((,...}}}.))).)))}..........),))))).}},,{((,,.({,(,,{.,|}}}.,,)),..))))||)),,,(((((((......)))))))........,,,......))))))}.)))))}.)))),))....)))).,,.}))},..)))))).|.....}))))))..))))

Transcripts

ID Sequence Length GC content
NM_002777.4 NCBI
GGACCCCACCAUGGCUCACCGGCCCCCCAGCCCUGCCCUGGCGUCCGUG… 987 nt 0.6646
Summary

Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; neutrophil extravasation; and positive regulation of GTPase activity. Located in azurophil granule lumen; cytosol; and plasma membrane raft. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the PRTN3 as one of 19 center genes commonly differentially expressed in blood across early-stage, middle-stage, and control groups following burn injury, indicating its association with burn injury progression [Wu et al. DOI:10.007/s10753-018-0829-0]. In mice, single-cell RNA sequencing following traumatic brain injury with clodronate pre-treatment revealed the PRTN3 as a defining granule gene for a neutrophil-like monocyte cluster, with its increased expression in whole blood monocytes correlating with a neuroprotective phenotype and improved injury outcomes [Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8].