Basic Information

Symbol
PSMA6
RNA class
mRNA
Alias
Proteasome 20S Subunit Alpha 6 PROS27 P27K IOTA Proteasome (Prosome, Macropain) Subunit, Alpha Type, 6 Multicatalytic Endopeptidase Complex Iota Chain Proteasome Subunit Alpha Type-6 Proteasome Subunit Alpha 6 Proteasome Subunit Alpha-1 27 KDa Prosomal Protein Proteasome Iota Chain Macropain Iota Chain MGC22756 MGC23846 MGC2333 PROS-27 Alpha-1 Testicular Secretory Protein Li 44 Proteasome Subunit Alpha1 Proteasome Subunit Iota Macropain Subunit Iota Proteasome Subunit Α1 Prosomal P27K Protein EC 3.4.25.1
Location (GRCh38)
14:35278633-35318734
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002791.3
Sequence length
1023.0 nt
GC content
0.4379

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-307.30 kcal/mol
Thermodynamic ensemble
Free energy: -326.74 kcal/mol
Frequency: 0.0000
Diversity: 231.52
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((.((((((((((((((((..((((((....))))))(((((.(((((((((((((.........(((((....((((.....)))).)))))))))))))))))).)))))(((..(((((((...(((((.((((....(((.(((((((.((((((((((.((((((((((............(((((((((.(((((((..((((((((((.((.((.......)).))))))..((((((.((........))...)))))).....(((...)))((.(((((..(((.(((((...))))).)))...)))))))((((((..((((((((((.(.((..((((((..(((((((............(((....)))(((((((((......).))).)))))........)))).)))..))))))...........)).).))))))...))))..))))))...))))))..))))))))))))))))..)))).)))))).)))))........)))))..))))))).)))....)))))))))...)).)))))..)))((((........)))).....))))))))................(((((((((((.......)))....((((...(((((.....((.((((...(((((((((....(((......)))...)))))))))...)))).))...))))).)))).......)))))))).)))))))).)))...((((((......))))))....(((((((.(((.......)))..((((((..........(((((((((((.(......))))))))(((...(((((((((.(((......)))...(((((........)))))))))))))))))....(((.((.....((((...)))))).)))(((((((((....)))).)))))))))...........)))))))))))))(((((((((........))))))))).
Thermodynamic Ensemble Prediction
{(((((.((((((((((((((((..((((((,,.,|}||||(((((.(((((((((((((.........(((((....((((.....)))).)))))))))))))))))).)))))(((..(({{{{{..,{{{{,{((({.,..(((.(((((((.((((((((((.((((((((((............(((((((((.(((((((..(((((((((((((.,({{,...((((((({((((((((((.((........))...)))))}}))))|{{...}}})))))))...||.,||,,{,,..{{{{{|||.....)))))}||,||,,||||,,,,}}}}}||,.((((((..(((((((..,...,,.{..(((....}}|(({{{{|||......},})).)))))........)))).)))..))))))..........,|}.|,...,}},,.)})},.,}},}}}..})))))..))))))))))))))))..)))),}))))).))))),.......}))))..))))))).)))..,.)))))}}}),,,}|,}}}}}..}))||||,.....,,))))..,..))))))))........,..,,,,.{({{(((((((.......}}}.||||,,{...{{|{{,,,|.((.((((...(((((((((....(((......)))...))))))))),..)))).)).,|))}},.||}|.......)))))))).)))))))).|,|{{.((((((......)))))).}}}|,{,((((........})))}.,((((((.{,,,.....||||{(((({{,(......)))))))}.((,,.(((((((((.(((......))).}.(((((........))))}))))))))),||..}}}}..,,....,((((...},,,..,}}}(((((((((....))))},)))),,,,...........)))))))))))},(((((((((........))))))))).

Transcripts

ID Sequence Length GC content
NM_001282232.1 NCBI
GCUCGAACUGGCUCCAGAGCCGUGAGUUCGGCAUGCAAGAGCGGAAGAA… 1139 nt 0.4495
NM_001282233.1 NCBI
GCUCGAACUGGCUCCAGAGCCGUGAGUUCGGCAUGCAAGAGCGGAAGAA… 996 nt 0.4458
NM_001282234.1 NCBI
AGAAUGUCAGUAUCCAAUAGGAUGCCAGUGGAAUUCCCUGACGAUUCCA… 1016 nt 0.4262
NM_002791.3 NCBI
GGAAGCAGUCGCUGCAACUUCCGGGAGGUGCUUGUGUGCCUGGUGCGGG… 1023 nt 0.4379
Summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Forensic Context

A study in rats demonstrated that acute ethanol exposure induces an open chromatin state at the promoter of the PSMA6 in the amygdala, as identified by ATAC-seq analysis [Krishnan et al. DOI:10.1038/S41380-022-01732-2].