| ID | Sequence | Length | GC content |
|---|---|---|---|
| GAUUCCCGGGACUAGGUUGCGGGAGAAAGCCUGUUGCGUGGAAGAUAAG… | 1619 nt | 0.5571 | |
| GAUUCCCGGGACUAGGUUGCGGGAGAAAGCCUGUUGCGUGGAAGAUAAG… | 1672 nt | 0.5562 | |
| GAUUCCCGGGACUAGGUUGCGGGAGAAAGCCUGUUGCGUGGAAGAUAAG… | 1805 nt | 0.5634 | |
| GAUUCCCGGGACUAGGUUGCGGGAGAAAGCCUGUUGCGUGGAAGAUAAG… | 1715 nt | 0.5627 |
This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
A study in mice demonstrated that the PSRC1 mRNA was up-regulated 2.95-fold in bone marrow cells 6 hours after 6.5 Gy whole-body ionizing radiation. This differential expression was validated by RT-PCR, showing good agreement with microarray data, and the gene is noted to be activated by p53 within the broader radiation response involving DNA replication/repair and apoptosis pathways [Dai et al. DOI:10.1080/09553000600857389]. This up-regulation occurred alongside other p53 pathway genes, indicating its role in the transcriptional response to radiation-induced DNA damage within the investigated biological system.