Basic Information

Symbol
PTK6
RNA class
mRNA
Alias
Protein Tyrosine Kinase 6 BRK PTK6 Protein Tyrosine Kinase 6 Tyrosine-Protein Kinase BRK Protein-Tyrosine Kinase 6 Breast Tumor Kinase EC 2.7.10.2 Protein-Tyrosine Kinase BRK EC 2.7.10
Location (GRCh38)
20:63528001-63537376
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005975.4
Sequence length
2953.0 nt
GC content
0.5757

Transcripts

ID Sequence Length GC content
NM_001256358.2 NCBI
ACGCCCAGCUCUGGGUGCUCCAGCUGGGCCACAGCCUGGUCCUGCCGCU… 2831 nt 0.5719
NM_005975.4 NCBI
ACGCCCAGCUCUGGGUGCUCCAGCUGGGCCACAGCCUGGUCCUGCCGCU… 2953 nt 0.5757
Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Forensic Context

No relevant information is available at the moment.