Basic Information

Symbol
PTMA
RNA class
mRNA
Alias
Prothymosin Alpha TMSA Gene Sequence 28 Prothymosin, Alpha (Gene Sequence 28) Prothymosin Alpha Protein Prothymosin, Alpha Prothymosin-I+/- Prothymosin-Α
Location (GRCh38)
2:231706895-231713552
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002823.5
Sequence length
1215.0 nt
GC content
0.4560

Transcripts

ID Sequence Length GC content
NM_001099285.2 NCBI
CCCCCACUGGCUGCUCUGAAAAGCCAUCUUUGCAUUGUUCCUCAUCCGC… 1218 nt 0.4565
NM_002823.5 NCBI
CCCCCACUGGCUGCUCUGAAAAGCCAUCUUUGCAUUGUUCCUCAUCCGC… 1215 nt 0.4560
Summary

Enables DNA-binding transcription factor binding activity and histone binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the PTMA gene, a marker of proliferative phenotype, was upregulated in the neutrophil-like monocyte cluster (C9) that emerged following clodronate liposome pre-treatment and controlled cortical impact brain injury [Erwin K. Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8]. This specific monocyte subset, characterized by this and other proliferative markers, was part of a broader immunoregulatory and neuroprotective response that reduced lesion volume, stabilized the blood-brain barrier, and improved cerebral blood flow when adoptively transferred into injured recipient mice. A study in humans identified ENST00000409321.5 as a down-regulated mRNA in peripheral blood mononuclear cells of ST-elevation myocardial infarction patients compared to non-ST-elevation myocardial infarction patients, with a fold change of 16.17, and it was classified as a diagnostic biomarker for acute myocardial infarction [Zhong et al. DOI:10.1097/MD.0000000000013066].