Basic Information

Symbol
PTP4A1
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase 4A1 PTPCAAX1 PRL-1 PRL1 Protein-Tyrosine Phosphatase Of Regenerating Liver 1 Protein Tyrosine Phosphatase Type IVA, Member 1 Protein Tyrosine Phosphatase Type IVA 1 Phosphatase Of Regenerating Liver 1 EC 3.1.3.48 Protein Tyrosine Phosphatase Type IVA Protein 1 Protein-Tyrosine Phosphatase 4a1 PVT1/PTP4A1 Fusion PTP(CAAX1) PTP(CAAXI) HH72
Location (GRCh38)
6:63521746-63583588
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003463.5
Sequence length
4621.0 nt
GC content
0.3603

Transcripts

ID Sequence Length GC content
NM_001385266.1 NCBI
GCCUCGGCGCGUGUAUUGGCUCCUUCGGCUGCGGGCCGGCUCGGCUACG… 4664 nt 0.3604
NM_001385267.2 NCBI
GCCUCGGCGCGUGUAUUGGCUCCUUCGGCUGCGGGCCGGCUCGGCUACG… 4719 nt 0.3672
NM_001385268.2 NCBI
GCCUCGGCGCGUGUAUUGGCUCCUUCGGCUGCGGGCCGGCUCGGCUACG… 4582 nt 0.3590
NM_003463.5 NCBI
GCCUCGGCGCGUGUAUUGGCUCCUUCGGCUGCGGGCCGGCUCGGCUACG… 4621 nt 0.3603
Showing 11 to 14 of 14 entries
Summary

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Forensic Context

A study in humans undergoing cardiac surgery with cardiopulmonary bypass identified the PTP4A1 as an oncogene inhibited by miR-339-5p in colon cancer, as mentioned in the discussion of the research [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015].