Basic Information

Symbol
PTP4A2
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase 4A2 PTPCAAX2 HU-PP-1 PRL-2 OV-1 PRL2 Ptp-IV1a Protein-Tyrosine Phosphatase Of Regenerating Liver 2 Protein Tyrosine Phosphatase Type IVA, Member 2 Protein Tyrosine Phosphatase Type IVA 2 Phosphatase Of Regenerating Liver 2 PTP(CAAXII) EC 3.1.3.48 PTP4A Protein Tyrosine Phosphatase IVA2 Protein Tyrosine Phosphatase IVA Protein-Tyrosine Phosphatase 4a2 Ptp-IV1b HH7-2 HH13
Location (GRCh38)
1:31906421-31944856
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_080391.4
Sequence length
3910.0 nt
GC content
0.4228

Transcripts

ID Sequence Length GC content
NM_001195100.2 NCBI
CCGGCUGCGCGCGCAGCGGUGGUGGUGGCGGCGCGAUCGGCCGGGCUGU… 3835 nt 0.4227
NM_001195101.2 NCBI
CCGGCUGCGCGCGCAGCGGUGGUGGUGGCGGCGCGAUCGGCCGGGCUGU… 3817 nt 0.4236
NM_001369858.1 NCBI
GUGUGUGUGGAAGGGAGAGAGCUGUGCGAGCGUGGGGGAGAGUUUUUCG… 3476 nt 0.3855
NM_001369859.1 NCBI
GUGUGUGUGGAAGGGAGAGAGCUGUGCGAGCGUGGGGGAGAGUGAGUUG… 3802 nt 0.3880
NM_001369860.1 NCBI
GUGUGUGUGGAAGGGAGAGAGCUGUGCGAGCGUGGGGGAGAGUGAGUUG… 3592 nt 0.3870
NM_080391.4 NCBI
CCGGCUGCGCGCGCAGCGGUGGUGGUGGCGGCGCGAUCGGCCGGGCUGU… 3910 nt 0.4228
Summary

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

Forensic Context

A study in rats demonstrated that the PTP4A2 was significantly downregulated in left ventricular tissues from an ischemic cardiomyopathy model created via coronary artery ligation [Wang et al. DOI:10.1007/s12031-018-1066-6].